Analytical Data
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Gene name
ZNF419
- Application
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Alternative Names
Zinc finger Protein 419; Zinc finger Protein 419A; ZN419_HUMAN; ZNF419
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96HQ0
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Expression Region
1-510 aa
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AA Sequence
MAAAALRDPA QVPVAADLLT DHEEGYVTFE DVAVYFSQEE WRLLDDAQRL LYRNVMLENF TLLASLGLAS SKTHEITQLE SWEEPFMPAW EVVTSAIPRG CWHGAEAEEA PEQIASVGLL SSNIQQHQKQ HCGEKPLKRQ EGRVPVLRSC KVHLSEKSLQ SREVGKALLI SSGVLKHQVT HTGEKSHRSS KSREAFHAGK RHYKCSECGK AFGQKYLLVQ HQRLHAGKKT YECSECGKLF RDMSNLFIHQ IVHTGERPYG CSNCGKSFSR NAHLIEHQRV HTGEKPFTCS ECGKAFRHNS TLVQHHKIHT GVRPYECSEC GKLFSFNSSL MKHQRIHTGE RPYKCSECGK FYSHKSNLIK HWRVHTGERP YKCSDCGKFF TQCSSLMQHQ KVHTGEKPFK CNECGRFFRE NSTLVRHQRV HTGAKPYECR ECGKFFSQSS TLMQHRKVHI GEKPFKCNEC GRLFRENSSL VKHQRVHTGA KPYECRECGK FFRHNSSLFK HRRIHTGEMQ
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Molecular Weight
58.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF419, a member of the zinc finger protein family, has garnered significant attention in molecular biology and genetics due to its potential roles in transcription regulation and cellular processes. As a transcription factor, ZNF419 is implicated in various biological functions, including cell differentiation, proliferation, and apoptosis. Its unique structural characteristics, featuring multiple zinc finger motifs, suggest a capacity for binding specific DNA sequences, which could influence gene expression patterns crucial for normal development and disease progression. Research has particularly focused on its involvement in cancer biology, where aberrant expression of ZNF419 may contribute to tumorigenesis. Additionally, studies are exploring its interactions with other proteins and signaling pathways, revealing its functional complexity within the cell. Understanding the mechanisms of ZNF419's action through recombinant protein studies could offer insights into its biological significance and therapeutic implications, paving the way for novel strategies in disease treatment and gene therapy. The production and characterization of ZNF419 recombinant proteins could further elucidate its role in cellular regulation and present opportunities for biotechnological applications.
