Analytical Data
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Gene name
ZNF3
- Application
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Alternative Names
ZNF3; KOX25; Zinc finger Protein 3; Zinc finger Protein HF.12; Zinc finger Protein HZF3.1; Zinc finger Protein KOX25
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P17036
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Expression Region
1-446 aa
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AA Sequence
METQADLVSQ EPQALLDSAL PSKVPAFSDK DSLGDEMLAA ALLKAKSQEL VTFEDVAVYF IRKEWKRLEP AQRDLYRDVM LENYGNVFSL DRETRTENDQ EISEDTRSHG VLLGRFQKDI SQGLKFKEAY EREVSLKRPL GNSPGERLNR KMPDFGQVTV EEKLTPRGER SEKYNDFGNS FTVNSNLISH QRLPVGDRPH KCDECSKSFN RTSDLIQHQR IHTGEKPYEC NECGKAFSQS SHLIQHQRIH TGEKPYECSD CGKTFSCSSA LILHRRIHTG EKPYECNECG KTFSWSSTLT HHQRIHTGEK PYACNECGKA FSRSSTLIHH QRIHTGEKPY ECNECGKAFS QSSHLYQHQR IHTGEKPYEC MECGGKFTYS SGLIQHQRIH TGENPYECSE CGKAFRYSSA LVRHQRIHTG EKPLNGIGMS KSSLRVTTEL NIREST
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Molecular Weight
50.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF3, a member of the zinc finger protein family, has garnered significant attention in molecular biology and biochemistry due to its pivotal role in gene regulation, cellular differentiation, and developmental processes. Its unique structure, characterized by multiple zinc finger motifs, enables ZNF3 to bind specific DNA sequences, influencing transcriptional activity. Research has shown that ZNF3 is involved in various cellular pathways, including cell cycle regulation and apoptosis, making it a potential target for therapeutic interventions in cancer and other diseases. Additionally, ZNF3 has been implicated in neurodevelopmental disorders, highlighting its importance in brain function. The production of recombinant ZNF3 protein facilitates detailed studies on its biochemical properties, interactions, and functional mechanisms, providing insights into its role in disease pathology. Advances in protein expression systems have made it feasible to generate high-quality ZNF3 for both in vitro and in vivo studies, allowing researchers to explore its potential as a biomarker or therapeutic target. Understanding the intricate functions of ZNF3 not only enhances our knowledge of gene regulatory networks but also opens up new avenues for therapeutic developments in regenerative medicine and cancer treatment. Consequently, investigating ZNF3 through recombinant protein technology remains a crucial aspect of current research, aiming to decode its multifaceted roles in health and disease.
