Analytical Data
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基因名
TRIM35
- Application
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别名
0710005M05Rik; A430106H13Rik; AW046487; Hemopoietic lineage switch Protein 5; HLS5; KIAA1098; Macrophage derived apoptosis inducing RBCC Protein; MAIR; MGC17233; mKIAA1098; NC8; Protein MAIR; Protein Nc8; TRI35_HUMAN; TRIM35; Tripartite motif containing 35; Tripartite motif containing Protein 35; Tripartite motif-containing Protein 35
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UPQ4
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表达区间
1-493 aa
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氨基酸序列
MERSPDVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRGCVSRCWE VQVSPTCPVC KDRASPADLR TNHTLNNLVE KLLREEAEGA RWTSYRFSRV CRLHRGQLSL FCLEDKELLC CSCQADPRHQ GHRVQPVKDT AHDFRAKCRN MEHALREKAK AFWAMRRSYE AIAKHNQVEA AWLEGRIRQE FDKLREFLRV EEQAILDAMA EETRQKQLLA DEKMKQLTEE TEVLAHEIER LQMEMKEDDV SFLMKHKSRK RRLFCTMEPE PVQPGMLIDV CKYLGSLQYR VWKKMLASVE SVPFSFDPNT AAGWLSVSDD LTSVTNHGYR VQVENPERFS SAPCLLGSRV FSQGSHAWEV ALGGLQSWRV GVVRVRQDSG AEGHSHSCYH DTRSGFWYVC RTQGVEGDHC VTSDPATSPL VLAIPRRLRV ELECEEGELS FYDAERHCHL YTFHARFGEV RPYFYLGGAR GAGPPEPLRI CPLHISVKEE LDG
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分子量
56.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRIM35, a member of the tripartite motif (TRIM) family of proteins, has emerged as a significant focus in cellular biology due to its multifaceted roles in immune responses, cellular stress, and tumorigenesis. This protein, characterized by a RING finger domain, B-Box, and coiled-coil region, is involved in various cellular processes including regulation of gene expression, protein ubiquitination, and autophagy. Recent studies have highlighted TRIM35's potential as a tumor suppressor, suggesting that it may inhibit cancer cell proliferation and metastasis by modulating key signaling pathways such as NF-κB and p53. Moreover, TRIM35 has been implicated in antiviral immunity, particularly through its ability to target viral components for degradation, thus playing a critical role in the host defense against infections. The exploration of TRIM35 as a recombinant protein in therapeutic applications is gaining momentum, as researchers aim to harness its biological functions to design innovative treatments for cancers and viral diseases, thus opening new avenues for research and clinical practice. Understanding the precise mechanisms by which TRIM35 exerts its functions could provide valuable insights into its potential as a biomarker and therapeutic target.
