Analytical Data
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Gene name
TRIM36
- Application
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Alternative Names
Acrosome RBCC Protein; E3 ubiquitin Protein ligase TRIM36; E3 ubiquitin-Protein ligase Trim36; Haprin; RBCC728; RING finger Protein 98; RNF98; TRI36_HUMAN; TRIM 36; Trim36; Tripartite motif containing 36; Tripartite motif containing Protein 36; Tripartite motif Protein 36; Tripartite motif-containing Protein 36; Zinc binding Protein Rbcc728; Zinc-binding Protein Rbcc728
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQ86
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Expression Region
1-728 aa
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AA Sequence
MSESGEMSEF GYIMELIAKG KVTIKNIERE LICPACKELF THPLILPCQH SICHKCVKEL LLTLDDSFND VGSDNSNQSS PRLRLPSPSM DKIDRINRPG WKRNSLTPRT TVFPCPGCEH DVDLGERGIN GLFRNFTLET IVERYRQAAR AATAIMCDLC KPPPQESTKS CMDCSASYCN ECFKIHHPWG TIKAQHEYVG PTTNFRPKIL MCPEHETERI NMYCELCRRP VCHLCKLGGN HANHRVTTMS SAYKTLKEKL SKDIDYLIGK ESQVKSQISE LNLLMKETEC NGERAKEEAI THFEKLFEVL EERKSSVLKA IDSSKKLRLD KFQTQMEEYQ GLLENNGLVG YAQEVLKETD QSCFVQTAKQ LHLRIQKATE SLKSFRPAAQ TSFEDYVVNT SKQTELLGEL SFFSSGIDVP EINEEQSKVY NNALINWHHP EKDKADSYVL EYRKINRDDE MSWNEIEVCG TSKIIQDLEN SSTYAFRVRA YKGSICSPCS RELILHTPPA PVFSFLFDEK CGYNNEHLLL NLKRDRVESR AGFNLLLAAE RIQVGYYTSL DYIIGDTGIT KGKHFWAFRV EPYSYLVKVG VASSDKLQEW LRSPRDAVSP RYEQDSGHDS GSEDACFDSS QPFTLVTIGM QKFFIPKSPT SSNEPENRVL PMPTSIGIFL DCDKGKVDFY DMDQMKCLYE RQVDCSHTLY PAFALMGSGG IQLEEPITAK YLEYQEDM
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Molecular Weight
83.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRIM36, a member of the tripartite motif (TRIM) family of proteins, has garnered increasing interest due to its potential roles in immune regulation and cancer biology. Studies have shown that TRIM proteins are involved in various cellular processes, including ubiquitination, which influences protein degradation, and immune responses by modulating the activity of different signaling pathways. Specifically, TRIM36 has been implicated in the negative regulation of inflammatory responses, making it a crucial player in maintaining cellular homeostasis. Research indicates that alterations in TRIM36 expression may contribute to the pathogenesis of various diseases, including autoimmune disorders and malignancies. Recent investigations have focused on understanding its molecular mechanisms, including interactions with other proteins and its effects on signal transduction pathways. The reorganization of TRIM36 as a recombinant protein allows for detailed studies of its functional properties and interactions within the immune system, facilitating insights into its role in health and disease. By employing techniques such as overexpression, silencing, and post-translational modification analysis, researchers aim to elucidate how TRIM36 can serve as a therapeutic target or biomarker for diseases, thereby highlighting its significance in biomedical research. Overall, the study of TRIM36 is pivotal in understanding the complex mechanisms underlying immune regulation and tumor biology, with the potential to inform the development of novel therapeutic strategies.
