Analytical Data
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基因名
PSMD6
- Application
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别名
PSMD6；KIAA0107；PFAAP4；26S proteasome non-ATPase regulatory subunit 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15008
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表达区间
1-389aa
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氨基酸序列
MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD SKNWQYQETI KKGDLLLNRV QKLSRVINM
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMD6, a crucial component of the 26S proteasome, plays a vital role in the ubiquitin-proteasome system, which is essential for maintaining cellular homeostasis by regulating protein degradation. Dysregulation of this system is implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Research on recombinant PSMD6 protein has gained momentum due to its potential as a therapeutic target and as a tool for studying proteasomal function. By generating and characterizing recombinant PSMD6, scientists aim to elucidate its structural and functional properties, investigate its interactions with other proteasome subunits, and understand its role in the degradation of ubiquitinated proteins. Additionally, recombinant PSMD6 can be utilized in high-throughput screening assays to identify compounds that modulate proteasome activity, thus offering new avenues for drug discovery. Understanding PSMD6's mechanisms can lead to novel therapeutic strategies aimed at restoring proteasomal function and mitigating the effects of diseases linked to its impairment. This makes PSMD6 not only a protein of interest for fundamental research but also a potential key player in the development of innovative treatments for complex diseases.
