Analytical Data
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Gene name
FAM161A
- Application
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Alternative Names
F161A_HUMAN; Fam161a; Family with sequence similarity 161; member A; FLJ13305; Hypothetical protein LOC84140; MGC129982; MGC129983; OTTHUMP00000201353; Protein FAM161A
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q3B820
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Expression Region
1-660aa
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AA Sequence
MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGASADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEEMKAAHMETMAKLEKMYQDKLHLKEVQPVVIREDSLSDSSRSVSEKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPNLEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPEPFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKKKFRANPVPASVFLPLYHDLVKQKGERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKKKTNRFKARPIPRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKCKHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADEENLKETRWPYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRKSEKERMREYQRGLEEREEKLKKRPLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQGGKVLEYFNNQETKSVTEDKESFNEEEKIEERENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH
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Molecular Weight
99 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FAM161A, a member of the FAM161 gene family, has garnered significant attention in the field of genetic and molecular research due to its association with inherited retinal diseases, particularly retinitis pigmentosa (RP). Mutations in the FAM161A gene have been identified as a common cause of autosomal recessive RP, leading to progressive vision loss and degeneration of photoreceptor cells in the retina. The exact function of FAM161A remains unclear, although it is believed to play a crucial role in cilia function and phototransduction pathways—integral processes for maintaining retinal health. Recent studies have focused on characterizing the biochemical properties of the FAM161A protein, using recombinant DNA technology to produce and analyze the protein in vitro. Such research aims to elucidate its structural features, protein-protein interactions, and the molecular mechanisms underlying its role in photoreceptor cell maintenance and survival. Understanding the function of FAM161A not only deepens our knowledge of retinal biology but also holds promise for developing targeted gene therapies. Given the complexity of retinal diseases and the challenge of treating genetic mutations, investigating FAM161A could pave the way for innovative therapeutic strategies that address the root causes of vision impairments, ultimately improving the quality of life for individuals affected by these debilitating conditions.
