Analytical Data
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基因名
FAM161A
- Application
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别名
F161A_HUMAN; Fam161a; Family with sequence similarity 161; member A; FLJ13305; Hypothetical protein LOC84140; MGC129982; MGC129983; OTTHUMP00000201353; Protein FAM161A
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q3B820
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表达区间
1-660aa
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氨基酸序列
MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGASADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEEMKAAHMETMAKLEKMYQDKLHLKEVQPVVIREDSLSDSSRSVSEKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPNLEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPEPFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKKKFRANPVPASVFLPLYHDLVKQKGERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKKKTNRFKARPIPRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKCKHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADEENLKETRWPYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRKSEKERMREYQRGLEEREEKLKKRPLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQGGKVLEYFNNQETKSVTEDKESFNEEEKIEERENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH
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分子量
99 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FAM161A, a member of the FAM161 gene family, has garnered significant attention in the field of genetic and molecular research due to its association with inherited retinal diseases, particularly retinitis pigmentosa (RP). Mutations in the FAM161A gene have been identified as a common cause of autosomal recessive RP, leading to progressive vision loss and degeneration of photoreceptor cells in the retina. The exact function of FAM161A remains unclear, although it is believed to play a crucial role in cilia function and phototransduction pathways—integral processes for maintaining retinal health. Recent studies have focused on characterizing the biochemical properties of the FAM161A protein, using recombinant DNA technology to produce and analyze the protein in vitro. Such research aims to elucidate its structural features, protein-protein interactions, and the molecular mechanisms underlying its role in photoreceptor cell maintenance and survival. Understanding the function of FAM161A not only deepens our knowledge of retinal biology but also holds promise for developing targeted gene therapies. Given the complexity of retinal diseases and the challenge of treating genetic mutations, investigating FAM161A could pave the way for innovative therapeutic strategies that address the root causes of vision impairments, ultimately improving the quality of life for individuals affected by these debilitating conditions.
