Analytical Data
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Gene name
TRGV3
- Application
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Alternative Names
TRGV3; TCRGV3; T cell receptor gamma variable 3; T-cell receptor gamma V-gamma-1.1 region
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P03979
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Expression Region
21-136 aa
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AA Sequence
NLEGRTKSVT RQTGSSAEIT CDLTVTNTFY IHWYLHQEGK APQRLLYYDV STARDVLESG LSPGKYYTHT PRRWSWILRL QNLIENDSGV YYCATWDRXK NYYKKLFGSG TTLVVT
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Molecular Weight
13.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRGV3 is a member of the T cell receptor gamma (TCRγ) gene family, playing a pivotal role in the immune response, particularly in the context of γδ T cells. These cells are a unique subset of T lymphocytes that recognize a wide range of antigens without the need for classical major histocompatibility complex (MHC) presentation. The study of TRGV3, alongside its associated TCR gene segments, has garnered attention due to its potential implications in immunotherapy and vaccine development, especially against cancers and infectious diseases. Recent advancements in molecular biology techniques have enabled researchers to explore the structure and function of TRGV3 recombinants, shedding light on their interaction with various antigens and potential therapeutic applications. Understanding the mechanisms by which TRGV3 contributes to T cell activation, differentiation, and tissue residency may pave the way for novel strategies in enhancing immune responses. Furthermore, its unique properties could be harnessed for biomarker discovery and the development of personalized immunotherapies. The ongoing research focuses on elucidating the biological functions of TRGV3, including its role in tumor immunity and protective responses against pathogens, thus highlighting its significance in the field of immunology.
