Analytical Data
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基因名
ACTN3
- Application
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别名
ACTN3;Alpha-actinin-3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q08043
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表达区间
325-608aa
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氨基酸序列
RKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDRLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYIT
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分子量
33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACTN3, also known as alpha-actinin-3, is a skeletal muscle-specific protein that plays a crucial role in the structural organization of muscle fibers and is implicated in muscle function and performance. The gene encoding this protein, ACTN3, is characterized by a polymorphism that results in either the presence (RR genotype) or absence (XX genotype) of the protein in individuals. This genetic variation has been extensively studied to understand its association with athletic performance, particularly in power and sprint athletes versus endurance athletes. Research has shown that individuals with the RR genotype tend to exhibit enhanced muscle strength and explosive power, likely due to the higher efficiency of fast-twitch muscle fibers, while those with the XX genotype may perform better in endurance-related activities. Furthermore, the functional implications of ACTN3 deficiency have been explored in relation to muscle physiology, recovery, and susceptibility to injury. The ongoing research into ACTN3 not only deepens our understanding of the genetic components of physical performance but also provides insights into potential therapeutic approaches for muscle-related diseases and conditions. The elucidation of the ACTN3 role in muscle dynamics continues to be a significant area of interest in exercise science, genetics, and sports medicine, contributing to the broader field of personalized training and rehabilitation strategies based on genetic profiling.












