Analytical Data
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基因名
TOB1
- Application
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别名
TOB1; TOB; TROB1; Protein Tob1; Transducer of erbB-2 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P50616
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表达区间
1-345 aa
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氨基酸序列
MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKKKY EGHWYPEKPY KGSGFRCIHI GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS YQIGEKGPVK VLYVDDNNEN GCELDKEIKN SFNPEAQVFM PISDPASSVS SSPSPPFGHS AAVSPTFMPR STQPLTFTTA TFAATKFGST KMKNSGRSNK VARTSPINLG LNVNDLLKQK AISSSMHSLY GLGLGSQQQP QQQQQPAQPP PPPPPPQQQQ QQKTSALSPN AKEFIFPNMQ GQGSSTNGMF PGDSPLNLSP LQYSNAFDVF AAYGGLNEKS FVDGLNFSLN NMQYSNQQFQ PVMAN
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分子量
38.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TOB1 (transducer of MITF and BRAFV600E) is a critical protein involved in various cellular processes, particularly those related to cancer biology and gene regulation. Its role as a regulator of MITF (Microphthalmia-associated Transcription Factor) suggests a significant involvement in melanocyte function and proliferation, making TOB1 an important focus in melanoma research. Mutations and aberrant expression of MITF and its regulatory pathways are often observed in melanoma, highlighting the relevance of TOB1 in tumorigenesis. Studies have shown that TOB1 can influence signaling pathways associated with growth and survival, thereby impacting cancer cell behavior and treatment response. The growing interest in TOB1 arises from its potential as a therapeutic target, with researchers exploring its mechanistic pathways to identify novel intervention strategies. Furthermore, understanding TOB1's molecular interactions and its effects on cellular processes may provide insights into the development of innovative treatments for melanoma and other cancers where TOB1 plays a pivotal role. As the landscape of cancer research evolves, the characterization and modulation of TOB1 could lead to breakthroughs in targeted therapies and improved patient outcomes.
