Analytical Data
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基因名
TNIK
- Application
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别名
EC 2.7.11.1 ; KIAA0551 ; Tnik; TNIK_HUMAN; Traf2 and NCK interacting kinase; Traf2 and NCK-interacting Protein kinase
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKE5
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表达区间
1-538 aa
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氨基酸序列
MKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSATALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
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分子量
86.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TNIK (Trinucleotide repeat containing kinase) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell growth, survival, and differentiation. Recent studies have highlighted its involvement in cancer progression and metastasis, prompting researchers to investigate its potential as a therapeutic target. The protein functions as a regulator of the Wnt signaling pathway, which is vital for embryonic development and tissue regeneration. Alterations in TNIK expression and activity have been linked to several types of malignancies, including colorectal cancer and hepatocellular carcinoma. The growing interest in TNIK has spurred a number of research efforts aimed at understanding its molecular mechanisms and biological functions. By developing TNIK recombinant proteins, researchers aim to elucidate the structure-function relationships that govern its kinase activity and interaction with downstream signaling partners. This research not only enhances our understanding of TNIK’s role in normal physiology and cancer biology but also paves the way for novel therapeutic strategies targeting TNIK in cancer treatment. Ultimately, understanding the precise mechanisms through which TNIK operates may contribute to the development of targeted therapies that can disrupt aberrant signaling pathways associated with cancer progression, leading to improved outcomes for patients suffering from malignancies linked to dysregulated TNIK activity.
