Analytical Data
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基因名
ESCO2
- Application
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别名
ESCO2N-acetyltransferase ESCO2; EC 2.3.1.-; Establishment factor-like protein 2; EFO2; EFO2p; hEFO2; Establishment of cohesion 1 homolog 2; ECO1 homolog 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q56NI9
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表达区间
1-601aa
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氨基酸序列
MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFNS
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分子量
93.06 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ESCO2 is a crucial protein involved in the regulation of sister chromatid cohesion during cell division. It is a member of theESCO family of proteins, specifically known for its role in the acetylation of cohesin, a protein complex that holds sister chromatids together until anaphase. Mutations in the ESCO2 gene have been linked to a rare genetic disorder known as Roberts syndrome, characterized by growth retardation, limb malformations, and various other developmental abnormalities. The study of ESCO2 and its associated pathways is essential for understanding the molecular mechanisms underlying chromosomal stability and segregation. Research on ESCO2 reconstitution proteins aims to elucidate the biochemical functions of ESCO2 in cohesin regulation and how its dysfunction can lead to genomic instability and associated diseases. This area of study not only sheds light on fundamental cellular processes but also provides potential therapeutic avenues for conditions arising from chromosomal missegregation. As a result, researchers are focused on characterizing ESCO2's interactions, post-translational modifications, and its role in the context of the cell cycle, which are vital for advancing our understanding of both normal cellular function and the pathogenesis of related disorders.
