Analytical Data
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Gene name
ERICH1
- Application
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Alternative Names
ERIC1_HUMAN; ERICH1; Glutamate-rich protein 1; HSPC319
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86X53
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Expression Region
1-443aa
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AA Sequence
MAAHRKHVFVEKVLQRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCWPEPSSCGSPENASSGDDTEDQDPHDQPKRRRIRKHKSKKKFKNPNNVLIEQAELEKQQSLLQEKSQRQHTDGTTISKNKKRKLKKKQQIKRKKAAGLAAKAAGVSFMYQPEDSSNEGEGVGEACEEDGVDTSEEDPTLAGEEDVKDTREEDGADASEEDLTRARQEEGADASEEDPTPAGEEDVKDAREEDGVDTIEEDLTRAGEEDGKDTREEDGADASEEDPTWAGEEEGADSGEEDGADASEEDDTITNEKAHSILNFLKSTQEMYFYDGVSRDAASAALADAAEELLDRLASHSMLPSDVSILYHMKTLLLLQDTERLKHALEMFPEHCTMPPDHARVISAFFSYWITHILPEKSSD
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Molecular Weight
75.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ERICH1 (E3 ubiquitin-protein ligase ERICH1) is a protein that plays a crucial role in various cellular processes, including cell signaling, regulation of the cell cycle, and apoptosis. Research has highlighted its involvement in neurodevelopmental disorders and cancer, wherein alterations in its expression or function can lead to significant pathological consequences. Prior studies have shown that ERICH1 interacts with several key signaling pathways, thereby influencing gene expression and protein degradation mechanisms. The recombinant expression of ERICH1 protein has gained attention as it enables researchers to study its structure, function, and interactions in detail. By producing ERICH1 in a controlled laboratory environment, scientists can assess its enzymatic activity, understand its role in ubiquitination processes, and explore its potential as a therapeutic target. Furthermore, elucidating the molecular mechanisms underlying ERICH1’s actions could lead to novel insights into disease progression and open avenues for the development of targeted treatments. Given the growing evidence connecting ERICH1 to critical biological functions and disease states, the study of its recombinant protein is essential for translating laboratory findings into clinical applications. Overall, the characterization of ERICH1 through recombinant technology is a promising area of research that could advance our understanding of its biological significance and therapeutic potential.
