Analytical Data
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Gene name
ZNF177
- Application
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Alternative Names
PIGX; Zinc finger Protein 177; ZN177_HUMAN; ZNF177
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13360
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Expression Region
1-481 aa
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AA Sequence
MAAGWLTTWS QNSVTFQEVA VDFSQEEWAL LDPAQKNLYK DVMLENFRNL ASVGYQLCRH SLISKVDQEQ LKTDERGILQ GDCADWETQL KPKDTIAMQN IPGGKTSNGI NTAENQPGEH SLECNHCGKF RKNTRFICTR YCKGEKCYKY IKYSKVFNHP STLRSHVSIH IGEKTLEFTD CRKAFNQESS LRKHLRTPTG QKFQEYEQCD MSFSLHSSCS VREQIPTGEK GDECSDYGKI SPLSVHTKTG SVEEGLECNE HEKTFTDPLS LQNCVRTHSG EMPYECSDCG KAFIFQSSLK KHMRSHTGEK PYECDHCGKS FSQSSHLNVH KRTHTGEKPY DCKECGKAFT VPSSLQKHVR THTGEKPYEC SDCGKAFIDQ SSLKKHTRSH TGEKPYECNQ CGKSFSTGSY LIVHKRTHTG EKTYECKECG KAFRNSSCLR VHVRTHTGEK PYKCIQCEKA FSTSTNLIMH KRIHNGQKLH E
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Molecular Weight
54.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF177, a member of the zinc finger protein family, has garnered interest in both basic and applied research due to its potential roles in various biological processes, including gene regulation, cellular differentiation, and signal transduction. The gene encoding ZNF177 is characterized by the presence of multiple zinc finger domains that enable specific DNA binding, suggesting a pivotal function in transcriptional regulation. Recent studies indicate that ZNF177 may be involved in critical pathways related to development and possibly in the modulation of immune responses. Given the importance of zinc finger proteins in therapeutic contexts, particularly for cancer and genetic disorders, the recombinant expression of ZNF177 protein allows for detailed investigation of its structure-function relationships and biological activities. This research could unveil novel insights into its roles in cellular processes and identify potential therapeutic targets. Additionally, the ability to produce ZNF177 as a recombinant protein facilitates high-throughput screening of small molecules that might modulate its activity, thus opening avenues for drug discovery and development. Understanding the functional implications of ZNF177 in physiological and pathological states will be crucial for advancing our knowledge of gene regulatory networks and enhancing strategies for intervention in diseases where its function is disrupted.
