Analytical Data
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基因名
TMEM176A
- Application
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别名
TMEM176A; HCA112; Transmembrane Protein 176A; Hepatocellular carcinoma-associated antigen 112
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96HP8
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表达区间
1-235 aa
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氨基酸序列
MGTADSDEMAPEAPQHTHIDVHIHQESALAKLLLTCCSALRPRATQARGSSRLLVASWVMQIVLGILSAVLGGFFYIRDYTLLVTSGAAIWTGAVAVLAGAAAFIYEKRGGTYWALLRTLLTLAAFSTAIAALKLWNEDFRYGYSYYNSACRISSSSDWNTPAPTQSPEEVRRLHLCTSFMDMLKALFRTLQAMLLGVWILLLLASLTPLWLYCWRMFPTKGKRDQKEMLEVSGI
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分子量
52.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMEM176A, a member of the transmembrane protein family, has garnered increasing attention in recent years due to its potential implications in various cellular processes and pathological conditions. This protein is primarily characterized by its involvement in immune response regulation and its expression in macrophages and dendritic cells. Research indicates that TMEM176A plays a pivotal role in modulating autophagy and immune signaling pathways, which can affect susceptibility to infections and the progression of autoimmune diseases. Moreover, its expression levels have been associated with cancer progression and the tumor microenvironment, suggesting that TMEM176A may serve as a biomarker for certain malignancies. Scientists aim to explore the functional mechanisms of TMEM176A through the generation of recombinant proteins, facilitating the study of its interactions with various signaling molecules and cellular pathways. By understanding the structural and functional characteristics of TMEM176A, researchers hope to uncover novel therapeutic targets and strategies for treating immune-related disorders and cancers. This line of investigation not only enhances our comprehension of TMEM176A's biological roles but also paves the way for the development of innovative treatments leveraging its unique properties.
