Analytical Data
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Gene name
TMEM116
- Application
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Alternative Names
TMEM116; Transmembrane Protein 116
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NCL8
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Expression Region
1-245 aa
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AA Sequence
MKHTQSGQSTSPLVIDFTCRVCQMAFVFSSLIPLLLMTPVFCLGNTSECFQNFSQSHKCILMHSPPSAMAELPPSANTSVCSTLYFYGIAIFLGSFVLSLLTIMVLLIRAQTLYKKFVKSTGFLGSEQWAVIHIVDQRVRFYPVAFFCCWGPAVILMIIKLTKPQDTKLRMALYVLQALTATSQGLLNCGVYGWTQHKFHQLKQEARRDADTQTPLLCSQKRFYSRGLNSLESTLTFPASTSTIF
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Molecular Weight
53.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TMEM116 is a member of the transmembrane protein 116 family that has garnered attention in recent years due to its potential roles in various biological processes, including cellular metabolism and membrane dynamics. Studies suggest that TMEM116 may be involved in the regulation of ion transport and cellular responses to stress, indicating its significance in maintaining cellular homeostasis. Research has shown that dysregulation of TMEM116 expression is associated with certain diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Given its pivotal roles, the recombinant expression of TMEM116 protein has become a focus of investigation. Producing TMEM116 as a recombinant protein allows researchers to study its structural properties, functional mechanisms, and interactions with other biomolecules in detail. Various expression systems, such as bacterial, yeast, or mammalian cells, are utilized to achieve high yields of this protein, enabling subsequent biochemical assays and functional analyses. Ongoing research aims to elucidate the precise functions of TMEM116, its molecular pathways, and its implications in health and disease, making it a promising candidate for further study in both basic and applied biomedical research. The development of TMEM116 recombinant proteins can lead to advancements in understanding its biological functions and possibly inform the design of targeted therapies in the future.
