Analytical Data
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Gene name
TMED5
- Application
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Alternative Names
Transmembrane emp24 domain-containing Protein 5. p24 family Protein gamma-2. p24gamma2. p28
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y3A6
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Expression Region
1-229 aa
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AA Sequence
MGDKIWLPFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPMPLKASLEIEYQVLDGAGLDIDFHLASPEGKTLVFEQRKSDGVHTVETEVGDYMFCFDNTFSTISEKVIFFELILDNMGEQAQEQEDWKKYITGTDILDMKLEDILESINSIKSRLSKSGHIQILLRAFEARDRNIQESNFDRVNFWSMVNLVVMVVVSAIQVYMLKSLFEDKRKSRT
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Molecular Weight
52.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TMED5, a member of the transmembrane emp24 domain (TMED) protein family, plays a crucial role in the transport of proteins within the Golgi apparatus and in the endoplasmic reticulum. It is involved in the regulation of protein sorting and trafficking, influencing cellular processes such as secretion and membrane integration. Significant interest has been sparked in researching TMED5 due to its potential implications in various diseases, including cancer and neurodegenerative disorders. Alterations in protein transport mechanisms can lead to pathological conditions, making TMED5 a significant candidate for therapeutic intervention. Additionally, understanding the biochemical properties and functional mechanisms of TMED5 can provide insights into the broader context of cellular transport systems. Recent studies have focused on the recombinant expression of TMED5 to investigate its structure-function relationships, interaction with other proteins, and its role in cellular homeostasis. By producing TMED5 as a recombinant protein, researchers aim to elucidate its functions and mechanisms of action, providing a foundation for developing new strategies to target TMED5-related pathways in disease. Overall, the study of recombinant TMED5 not only enhances our understanding of protein transport but also opens new avenues for potential therapeutic applications in treating diseases linked to protein misfolding and trafficking defects.
