Analytical Data
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基因名
PPP1R1B
- Application
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别名
PPP1R1B；DARPP32；Protein phosphatase 1 regulatory subunit 1B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UD71
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表达区间
1-168aa
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氨基酸序列
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERPPP
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分子量
23.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPP1R1B, also known as Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B, plays a crucial role in regulating protein phosphatase 1 (PP1) activity, an essential component in various cellular processes such as cell division, metabolism, and signal transduction. The dysregulation of PP1 has been implicated in numerous diseases, including cancer and neurodegenerative disorders. The study of PPP1R1B and its recombinant protein is significant as it contributes to our understanding of PP1 regulatory mechanisms and offers insights into the potential therapeutic targets for drug development. By using recombinant DNA technology, researchers can produce purified PPP1R1B proteins, allowing for detailed studies of their biochemical properties, interactions with various substrates and regulatory proteins, and their functional implications in cellular signaling pathways. Understanding the structure-function relationship of PPP1R1B can lead to the identification of specific inhibitors or modulators that may restore normal PP1 function in pathological conditions. Accordingly, ongoing research focuses on elucidating the molecular mechanisms by which PPP1R1B influences PP1 activity, aiming to uncover novel strategies for therapeutic intervention against diseases associated with PP1 dysregulation.
