Analytical Data
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Gene name
TMED1
- Application
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Alternative Names
IL1RL1 binding Protein; IL1RL1L; IL1RL1LG; Interleukin-1 receptor-like 1 ligand; Interleukin1 receptor like 1 ligand; MGC1270; p24 family Protein gamma 1; p24gamma1; Putative T1/ST2 receptor binding Protein; Putative T1/ST2 receptor-binding Protein; ST2L; T1/ST2 receptor binding Protein; TMED 1; Tmed1; TMED1_HUMAN; Tp24; Transmembrane emp24 domain containing 1; Transmembrane emp24 domain containing Protein 1; Transmembrane emp24 domain-containing Protein 1; Transmembrane emp24 Protein transport domain containing 1; Transmembrane p24 trafficking Protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13445
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Expression Region
1-227 aa
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AA Sequence
MMAAGAALALALWLLMPPVEVGGAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT
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Molecular Weight
51.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMED1, part of the transmembrane emp24-domain (TMED) family, is a crucial protein involved in the trafficking and processing of glycoproteins within the endoplasmic reticulum (ER) and the Golgi apparatus. The TMED family plays a significant role in the transport of proteins that are essential for various cellular functions. Research on TMED1 has gained momentum due to its potential implications in diseases such as cancer, where altered glycosylation patterns can significantly affect cell signaling and tumor progression. Understanding the structure-function relationship of TMED1 and its interactions with other cellular components is vital for elucidating its role in protein transport mechanisms. Furthermore, the recombinant expression of TMED1 allows for detailed studies into its functional properties and interactions, making it a valuable tool for developing therapeutic strategies aimed at correcting glycosylation defects. As researchers continue to explore the implications of TMED1 in health and disease, the development of recombinant TMED1 proteins offers promising insights into targeted treatments and diagnostic approaches.
