Analytical Data
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基因名
TLX3
- Application
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别名
homeo box 11-like 2; Homeobox Protein Hox 11L2; Homeobox Protein Hox-11L2; HOX11 L2; HOX11L2; RNX; T cell leukemia homeobox 3; T cell leukemia homeobox Protein 3; T-cell leukemia homeobox Protein 3; TLX 3; TLX3; TLX3_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43711
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表达区间
1-291 aa
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氨基酸序列
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG RPGATYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V
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分子量
31.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TLX3, an essential transcription factor, plays a pivotal role in T-cell development and is implicated in various lymphoid malignancies, particularly T-cell acute lymphoblastic leukemia (T-ALL). Research has highlighted that TLX3 gene rearrangements are often associated with specific chromosomal translocations, leading to aberrant expression and contributing to oncogenesis. Understanding TLX3 at the molecular level is crucial for elucidating the pathways involved in T-cell differentiation and malignancy. The recombinant production of TLX3 protein holds significant potential for advanced research into its biological functions and interactions with other cellular components. This knowledge could pave the way for novel therapeutic strategies targeting TLX3 signaling pathways in T-ALL and other related disorders. Furthermore, characterizing the structural properties of TLX3 can enhance our understanding of its regulatory mechanisms and downstream effects. As such, the study of TLX3 recombinant protein is vital for both fundamental immunology and the development of targeted therapies in hematological malignancies.
