Analytical Data
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Gene name
TLX3
- Application
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Alternative Names
homeo box 11-like 2; Homeobox Protein Hox 11L2; Homeobox Protein Hox-11L2; HOX11 L2; HOX11L2; RNX; T cell leukemia homeobox 3; T cell leukemia homeobox Protein 3; T-cell leukemia homeobox Protein 3; TLX 3; TLX3; TLX3_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43711
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Expression Region
1-291 aa
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AA Sequence
MEAPASAQTP HPHEPISFGI DQILNSPDQD SAPAPRGPDG ASYLGGPPGG RPGATYPSLP ASFAGLGAPF EDAGSYSVNL SLAPAGVIRV PAHRPLPGAV PPPLPSALPA MPSVPTVSSL GGLNFPWMES SRRFVKDRFT AAAALTPFTV TRRIGHPYQN RTPPKRKKPR TSFSRVQICE LEKRFHRQKY LASAERAALA KSLKMTDAQV KTWFQNRRTK WRRQTAEERE AERQQASRLM LQLQHDAFQK SLNDSIQPDP LCLHNSSLFA LQNLQPWEED SSKVPAVTSL V
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Molecular Weight
31.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TLX3, an essential transcription factor, plays a pivotal role in T-cell development and is implicated in various lymphoid malignancies, particularly T-cell acute lymphoblastic leukemia (T-ALL). Research has highlighted that TLX3 gene rearrangements are often associated with specific chromosomal translocations, leading to aberrant expression and contributing to oncogenesis. Understanding TLX3 at the molecular level is crucial for elucidating the pathways involved in T-cell differentiation and malignancy. The recombinant production of TLX3 protein holds significant potential for advanced research into its biological functions and interactions with other cellular components. This knowledge could pave the way for novel therapeutic strategies targeting TLX3 signaling pathways in T-ALL and other related disorders. Furthermore, characterizing the structural properties of TLX3 can enhance our understanding of its regulatory mechanisms and downstream effects. As such, the study of TLX3 recombinant protein is vital for both fundamental immunology and the development of targeted therapies in hematological malignancies.
