Analytical Data
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基因名
TIMM13
- Application
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别名
Mitochondrial import inner membrane translocase subunit TIM13; Mitochondrial import inner membrane translocase subunit Tim13B; ppv1; TIM 13; TIM13; TIM13_HUMAN; TIM13B; TIMM 13; Timm13; TIMM13A; TIMM13B; Translocase of inner mitochondrial membrane 13 homolog
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5L4
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表达区间
1-95 aa
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氨基酸序列
MEGGFGSDFG GSGSGKLDPG LIMEQVKVQI AVANAQELLQ RMTDKCFRKC IGKPGGSLDN SEQKCIAMCM DRYMDAWNTV SRAYNSRLQR ERANM
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分子量
10.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIMM13, or Translocase of Inner Mitochondrial Membrane 13, is a protein that plays a critical role in mitochondrial protein import and chaperone functions. Located in the inner mitochondrial membrane, TIMM13 is essential for maintaining mitochondrial integrity and function, as it facilitates the proper translocation of precursor proteins into the mitochondria. Research on TIMM13 has gained prominence due to its involvement in various mitochondrial diseases and its potential link to neurodegenerative disorders. Dysfunctions in mitochondrial protein import are known to contribute to pathologies such as Alzheimer’s, Parkinson’s, and other conditions associated with mitochondrial dysfunction. Given the rising incidence of these diseases globally, understanding the structural and functional properties of TIMM13 could provide valuable insights into therapeutic interventions. Studies have also indicated that TIMM13 is associated with the regulation of mitochondrial dynamics and can influence apoptosis. As such, investigating TIMM13 not only enhances our understanding of mitochondrial biology but also holds promise for discovering new targets for drug development and therapies aimed at mitigating mitochondrial-related diseases. Ongoing research is focused on characterizing TIMM13’s mechanisms of action, its interaction with other mitochondrial proteins, and its role in cellular homeostasis. This protein thus emerges as a significant subject of interest for both basic and translational research in the field of mitochondrial medicine.
