Analytical Data
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Gene name
ZFP36L2
- Application
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Alternative Names
BRF2; Butyrate response factor 2; C3H1 type-like 2; EGF response factor 2; EGF-response factor 2; ERF 2; ERF-2; ERF2; Protein TIS11D; RNF162C; TIS11D; TISD_HUMAN; ZFP36 like 2; ZFP36 ring finger Protein like 2; ZFP36-like 2; Zfp36l2; Zinc finger Protein 36; Zinc finger Protein 36. C3H type like 1; zinc finger Protein 36. C3H type like 2; Zinc finger Protein 36. C3H1 type like 2; Zinc finger Protein. C3H type. 36 like 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P47974
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Expression Region
1-497 aa
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AA Sequence
MSTTLLSAFYDVDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAPSSGFAPGFLRRHSASNLHALAHPAPSPGSCSPKFPGAANGSSCGSAAAGGPTSYGTLKEPSGGGGTALLNKENKFRDRSFSENGDRSQHLLHLQQQQKGGGGSQINSTRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGASGDLRAFGTRDALHLGFPREPRPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSCSSASSCSSSASSCSSASAASTPSGAPTCCASAAAAAAAALLYGTGGAEDLLAPGAPCAACSSASCANNAFAFGPELSSLITPLAIQTHNFAAVAAAAYYRSQQQQQQQQQQGLAPPAQPPAPPSATLPAGAAAPPSPPFSFQLPRRLSDSPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD
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Molecular Weight
77.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ZFP36L2, a member of the ZFP36 family of proteins, plays a crucial role in regulating mRNA stability and degradation, thereby influencing gene expression post-transcriptionally. Research has shown that ZFP36L2 interacts with AU-rich elements (AREs) in the 3' untranslated regions (3' UTRs) of target mRNAs, promoting decay and thus serving as a key regulator in various physiological and pathological processes, including inflammation, cell differentiation, and cancer progression. Given its significant involvement in mRNA metabolism, ZFP36L2 has garnered attention as a potential therapeutic target and biomarker in diseases characterized by dysregulated gene expression. Recent studies have focused on the structural and functional characterization of ZFP36L2 recombinant protein to elucidate its mechanisms of action, including the identification of binding partners and downstream effects on gene regulation. Investigating ZFP36L2 provides insights into the post-transcriptional control mechanisms that are vital for cellular homeostasis and has potential implications for developing strategies to modulate gene expression in disease contexts.
