Analytical Data
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基因名
ZFP36L2
- Application
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别名
BRF2; Butyrate response factor 2; C3H1 type-like 2; EGF response factor 2; EGF-response factor 2; ERF 2; ERF-2; ERF2; Protein TIS11D; RNF162C; TIS11D; TISD_HUMAN; ZFP36 like 2; ZFP36 ring finger Protein like 2; ZFP36-like 2; Zfp36l2; Zinc finger Protein 36; Zinc finger Protein 36. C3H type like 1; zinc finger Protein 36. C3H type like 2; Zinc finger Protein 36. C3H1 type like 2; Zinc finger Protein. C3H type. 36 like 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P47974
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表达区间
1-497 aa
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氨基酸序列
MSTTLLSAFYDVDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAPSSGFAPGFLRRHSASNLHALAHPAPSPGSCSPKFPGAANGSSCGSAAAGGPTSYGTLKEPSGGGGTALLNKENKFRDRSFSENGDRSQHLLHLQQQQKGGGGSQINSTRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGASGDLRAFGTRDALHLGFPREPRPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSCSSASSCSSSASSCSSASAASTPSGAPTCCASAAAAAAAALLYGTGGAEDLLAPGAPCAACSSASCANNAFAFGPELSSLITPLAIQTHNFAAVAAAAYYRSQQQQQQQQQQGLAPPAQPPAPPSATLPAGAAAPPSPPFSFQLPRRLSDSPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD
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分子量
77.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZFP36L2, a member of the ZFP36 family of proteins, plays a crucial role in regulating mRNA stability and degradation, thereby influencing gene expression post-transcriptionally. Research has shown that ZFP36L2 interacts with AU-rich elements (AREs) in the 3' untranslated regions (3' UTRs) of target mRNAs, promoting decay and thus serving as a key regulator in various physiological and pathological processes, including inflammation, cell differentiation, and cancer progression. Given its significant involvement in mRNA metabolism, ZFP36L2 has garnered attention as a potential therapeutic target and biomarker in diseases characterized by dysregulated gene expression. Recent studies have focused on the structural and functional characterization of ZFP36L2 recombinant protein to elucidate its mechanisms of action, including the identification of binding partners and downstream effects on gene regulation. Investigating ZFP36L2 provides insights into the post-transcriptional control mechanisms that are vital for cellular homeostasis and has potential implications for developing strategies to modulate gene expression in disease contexts.
