Analytical Data
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基因名
EHD4
- Application
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别名
EHD4; HCA10; HCA11; PAST4; FKSG7EH domain-containing protein 4; Hepatocellular carcinoma-associated protein 10/11; PAST homolog 4
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H223
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表达区间
1-541aa
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氨基酸序列
MFSWMGRQAGGRERAGGADAVQTVTGGLRSLYLRKVLPLEEAYRFHEFHSPALEDADFENKPMILLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISVIDSPGILSGEKQRISRGYDFCQVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKVHAYIISYLKKEMPSVFGKENKKRELISRLPEIYIQLQREYQISAGDFPEVKAMQEQLENYDFTKFHSLKPKLIEAVDNMLSNKISPLMNLISQEETSTPTQLVQGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEEEFALAKHLIKIKLDGYELPSSLPPHLVPPSHRKSLPKAD
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分子量
85.25 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EHD4 (Eps15 Homology Domain containing protein 4) is part of the EHD family of proteins, which are known to play critical roles in endocytic and recycling pathways within cells. Research into EHD4 has gained momentum due to its involvement in various cellular processes, including membrane dynamics, endosomal trafficking, and regulation of vesicular transport. Studies have shown that EHD4 interacts with specific membrane proteins and assists in the recycling of receptors and other molecules, impacting vital functions such as nutrient uptake, signal transduction, and cellular homeostasis. Moreover, EHD4 has been implicated in several diseases, including neurodegenerative disorders and cancer, where its dysregulation can disrupt normal cellular functions. Understanding the molecular mechanisms governing EHD4's activity is essential for elucidating its role in health and disease, and it presents potential therapeutic targets for interventions. Recent advances in structural biology and biochemistry have provided insights into the conformational changes and interactions of EHD4, highlighting its importance in maintaining cellular integrity and function. The ongoing investigation of EHD4 and its interactions continues to reveal its multifaceted roles in cellular machinery, which is crucial for both fundamental biological processes and the development of disease-relevant therapeutic strategies.
