Analytical Data
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基因名
TSHR
- Application
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别名
TSHR；LGR3；Thyrotropin receptor
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种属
Human
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表达系统
E. coli
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标签
N-terminal His-Tag
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16473
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表达区间
21-413aa
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氨基酸序列
GMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSN LPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLL KFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTL KLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQT SVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQK KIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQ DTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVC TPKSDEFNPCEDIMG
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分子量
48.3kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
Thyroid-stimulating hormone receptor (TSHR) plays a crucial role in regulating thyroid function and maintaining metabolic homeostasis by mediating the effects of thyroid-stimulating hormone (TSH). Dysregulation of TSHR signaling is implicated in various thyroid disorders, including hyperthyroidism and hypothyroidism, as well as autoimmune conditions like Graves' disease and Hashimoto's thyroiditis. Given its significance, researchers have been keen on studying TSHR to unravel its complex signaling mechanisms and structural characteristics. The generation of recombinant TSHR proteins has become a key focus, as these proteins serve as essential tools for investigating receptor behavior, drug interactions, and antibody development. Utilizing recombinant DNA technology, scientists can produce active TSHR proteins that mimic the natural receptor, facilitating biochemical assays and structural biology studies. The insights gained from TSHR recombinant studies can lead to novel therapeutic strategies and improve our understanding of thyroid pathophysiology, ultimately contributing to better management of thyroid-related diseases and enhancing patient outcomes.
