Analytical Data
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Gene name
TSHR
- Application
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Alternative Names
TSHR;LGR3;Thyrotropin receptor
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Species
Human
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Source
E. coli
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Tag
N-terminal His-Tag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P16473
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Expression Region
21-413aa
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AA Sequence
GMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSN LPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLL KFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTL KLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQT SVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQK KIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQ DTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVC TPKSDEFNPCEDIMG
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Molecular Weight
48.3kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
Thyroid-stimulating hormone receptor (TSHR) plays a crucial role in regulating thyroid function and maintaining metabolic homeostasis by mediating the effects of thyroid-stimulating hormone (TSH). Dysregulation of TSHR signaling is implicated in various thyroid disorders, including hyperthyroidism and hypothyroidism, as well as autoimmune conditions like Graves' disease and Hashimoto's thyroiditis. Given its significance, researchers have been keen on studying TSHR to unravel its complex signaling mechanisms and structural characteristics. The generation of recombinant TSHR proteins has become a key focus, as these proteins serve as essential tools for investigating receptor behavior, drug interactions, and antibody development. Utilizing recombinant DNA technology, scientists can produce active TSHR proteins that mimic the natural receptor, facilitating biochemical assays and structural biology studies. The insights gained from TSHR recombinant studies can lead to novel therapeutic strategies and improve our understanding of thyroid pathophysiology, ultimately contributing to better management of thyroid-related diseases and enhancing patient outcomes.











