Analytical Data
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Gene name
TFAP2B
- Application
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Alternative Names
Activating enhancer binding Protein 2 beta; Activating enhancer-binding Protein 2-beta; AP 2B; AP2 B; AP2-beta; AP2B; AP2B_HUMAN; AP2beta; MGC21381; OTTHUMP00000039925; PDA2; TFAP 2B; Tfap2b; Transcription factor AP 2 beta; Transcription factor AP-2-beta; Transcription factor AP2 beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92481
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Expression Region
1-460 aa
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AA Sequence
MHSPPRDQAA IMLWKLVENV KYEDIYEDRH DGVPSHSSRL SQLGSVSQGP YSSAPPLSHT PSSDFQPPYF PPPYQPLPYH QSQDPYSHVN DPYSLNPLHQ PQQHPWGQRQ RQEVGSEAGS LLPQPRAALP QLSGLDPRRD YHSVRRPDVL LHSAHHGLDA GMGDSLSLHG LGHPGMEDVQ SVEDANNSGM NLLDQSVIKK VPVPPKSVTS LMMNKDGFLG GMSVNTGEVF CSVPGRLSLL SSTSKYKVTV GEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRSLRERLEK IGLNLPAGRR KAANVTLLTS LVEGEAVHLA RDFGYICETE FPAKAVSEYL NRQHTDPSDL HSRKNMLLAT KQLCKEFTDL LAQDRTPIGN SRPSPILEPG IQSCLTHFSL ITHGFGAPAI CAALTALQNY LTEALKGMDK MFLNNTTTNR HTSGEGPGSK TGDKEEKHRK
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Molecular Weight
50.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TFAP2B, encoded by the TFAP2B gene, is a member of the Activator Protein-2 (AP-2) transcription factor family, which plays a crucial role in various biological processes, including embryonic development, cell differentiation, and tissue-specific gene expression. Research has highlighted TFAP2B's involvement in pivotal cellular functions, particularly in the regulation of genes associated with cellular growth, apoptosis, and responses to external stimuli. Importantly, TFAP2B has been implicated in several pathological conditions, including cancer, where its aberrant expression is often linked to tumorigenesis and metastasis. The study of TFAP2B as a recombinant protein has gained traction, allowing for better understanding of its structural and functional properties. By producing and analyzing TFAP2B in vitro, researchers are able to elucidate the specific molecular mechanisms by which it regulates gene expression in various contexts. Additionally, recombinant TFAP2B serves as a valuable tool for investigating its interactions with other proteins and transcription factors, shedding light on its role in developmental biology and disease. Given its importance in mediating key biological responses, TFAP2B continues to be a focus of research aimed at uncovering novel therapeutic targets for diseases where TFAP2B dysregulation plays a critical role.
