Analytical Data
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基因名
ACTHR
- Application
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别名
ACTHR；ACTHR；Adrenocorticotropic hormone receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q01718
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表达区间
1-297aa
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氨基酸序列
MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
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分子量
33.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACTHR, or Activin A receptor type 2B, is a pivotal component of the Activin signaling pathway, which plays a crucial role in numerous biological processes, including embryonic development, cellular differentiation, and tissue homeostasis. Aberrant Activin signaling has been implicated in various pathologies, such as cancer, fibrosis, and autoimmune diseases, highlighting the therapeutic potential of targeting this pathway. The recombinant protein of ACTHR is used to study its structure-function relationships and to elucidate the molecular mechanisms underlying its interactions with ligands and other signaling components. The production of recombinant ACTHR allows researchers to investigate its binding affinity to Activin ligands, assess the effects of various mutations, and evaluate the downstream signaling cascades it triggers. Understanding the precise roles of ACTHR in cellular contexts can lead to novel therapeutic strategies for diseases associated with its dysregulation. The study of ACTHR as a recombinant protein also provides insights into the development of small-molecule inhibitors or antibodies that could modulate its activity, offering new avenues for intervention in diseases where Activin signaling is aberrant. Overall, research on ACTHR and its recombinant form is essential for advancing our knowledge of the biological roles of Activins and their receptors in health and disease.
