Analytical Data
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Gene name
EDG6
- Application
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Alternative Names
S1PR4; EDG6; Sphingosine 1-phosphate receptor 4; S1P receptor 4; S1P4; Endothelial differentiation G-protein coupled receptor 6; Sphingosine 1-phosphate receptor Edg-6; S1P receptor Edg-6
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95977
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Expression Region
1-384aa
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AA Sequence
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
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Molecular Weight
67.98 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EDG6, also known as sphingosine-1-phosphate receptor 3 (S1PR3), is a member of the endothelial differentiation gene (EDG) family of G protein-coupled receptors that has garnered significant attention in recent years due to its role in various physiological and pathological processes. Research indicates that EDG6 is involved in regulating immune responses, vascular development, and maintaining cellular homeostasis, primarily through its interaction with sphingosine-1-phosphate (S1P), a bioactive lipid mediator. Dysregulation of EDG6 signaling has been implicated in various diseases, including cancer, cardiovascular disorders, and autoimmune diseases, making it an attractive target for therapeutic intervention. The development of recombinant EDG6 proteins allows for a deeper understanding of its structure-function relationships, signaling pathways, and potential as a drug target. By producing and characterizing these recombinant proteins, researchers aim to elucidate the molecular mechanisms of EDG6 action, investigate its interaction with ligands and downstream effectors, and assess its therapeutic potential in modulating immune responses and tumor progression. Moreover, studying the EDG6 receptor in a controlled environment facilitates the identification of novel small molecule modulators that could serve as potential drugs. Overall, the research on EDG6 recombinant proteins is pivotal in advancing our understanding of this receptor's biological significance and its potential implications in medicine.
