Analytical Data
-
Gene name
DNAJC1
- Application
-
Alternative Names
DnaJ (Hsp40) homolog subfamily C member 1; DnaJ homolog subfamily C member 1; DnaJ like protein; DnaJ protein homolog MTJ1; Dnajc1; DNAJL1; DNJC1_HUMAN; ERdj1; HTJ1; MGC131954; MTJ1
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q96KC8
-
Expression Region
1-340aa
-
AA Sequence
MKPQWHDLLPCKLGIWFCLTLKALPHLIQDAGQFYAKYKETRLKEKEDALTRTELETLQKQKKVKKPKPEFPVYTPLETTYIQSYDHGTSIEEIEEQMDDWLENRNRTQKKQAPEWTEEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATTLPDDMITQREDAEGVAAEEEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELALQQYPRGSSDCWDKIARCVPSKSKEDCIARYKLLVELVQKKKQAKS
-
Molecular Weight
63.14 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DNAJC1, a member of the DnaJ family of molecular chaperones, plays a crucial role in protein folding and cellular stress responses. Recent studies have highlighted its importance in various cellular processes, including mitochondrial function and the regulation of protein aggregation. Mutations or dysregulation of DNAJC1 have been implicated in several neurodegenerative diseases, particularly Parkinson's disease, underscoring its potential as a therapeutic target. Researchers are increasingly focused on recombinant DNAJC1 protein to elucidate its functional mechanisms, understand its interactions with other cellular proteins, and explore its role in disease pathology. The development of recombinant DNAJC1 allows for detailed biophysical and biochemical characterization, paving the way for potential interventions that could mitigate the effects of mutations or enhance its chaperone activities. This research is critical for advancing our understanding of protein misfolding diseases and developing innovative therapeutic strategies that could leverage DNAJC1's chaperone properties to restore cellular health and function.
