Analytical Data
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基因名
VANGL1
- Application
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别名
VANGL1；STB2；Vang-like Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TAA9
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表达区间
1-524aa
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氨基酸序列
MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGND STRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLG LLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMP RVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVL LELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKF RAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKAR LVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSM ESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIV FVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VANGL1, a crucial gene involved in the planar cell polarity (PCP) signaling pathway, has garnered significant attention in the fields of developmental biology and cancer research. Initially identified in the context of vertebrate embryogenesis, VANGL1 plays a pivotal role in coordinating cellular orientation and tissue organization during processes such as neurulation and organ development. Mutations in the VANGL1 gene have been linked to various congenital disorders, including neural tube defects and craniofacial abnormalities, underscoring its importance in proper embryonic patterning. Additionally, emerging studies suggest that VANGL1 may influence tumorigenesis and cancer progression by modulating cell movement and polarity. Given its dual role in development and disease, researchers are increasingly focusing on characterizing VANGL1 through recombinant protein studies. These investigations aim to elucidate its structural properties, interaction with other PCP components, and functional implications in both normal physiology and pathological conditions. By leveraging recombinant technologies, scientists hope to develop targeted therapies that can manipulate the VANGL1 signaling pathway, potentially offering new strategies for treating developmental disorders and cancers linked to impaired planar cell polarity.
