Analytical Data
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基因名
STAC3
- Application
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别名
MGC2793; SH3 and cysteine rich domain 3; SH3 and cysteine rich domain-containing protein 3; SH3 and cysteine-rich domain-containing protein 3; stac3; STAC3_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96MF2
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表达区间
1-364 aa
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氨基酸序列
MTEKEVLESP KPSFPAETRQ SGLQRLKQLL RKGSTGTKEM ELPPEPQANG EAVGAGGGPI YYIYEEEEEE EEEEEEPPPE PPKLVNDKPH KFKDHFFKKP KFCDVCARMI VLNNKFGLRC KNCKTNIHEH CQSYVEMQRC FGKIPPGFHR AYSSPLYSNQ QYACVKDLSA ANRNDPVFET LRTGVIMANK ERKKGQADKK NPVAAMMEEE PESARPEEGK PQDGNPEGDK KAEKKTPDDK HKQPGFQQSH YFVALYRFKA LEKDDLDFPP GEKITVIDDS NEEWWRGKIG EKVGFFPPNF IIRVRAGERV HRVTRSFVGN REIGQITLKK DQIVVQKGDE AGGYVKVYTG RKVGLFPTDF LEEI
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分子量
41.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STAC3, a member of the STAC family of proteins, has garnered significant attention in the field of molecular biology and genetics due to its critical role in calcium signaling and skeletal muscle function. Research indicates that STAC3 interacts with the voltage-dependent calcium channel (CaV1.1), influencing its activity and regulation. Mutations in the STAC3 gene have been associated with severe muscle disorders, particularly the congenital myopathy known as "STAC3 myopathy," characterized by muscle weakness and impaired motor function. Understanding the structural and functional properties of STAC3 is essential for elucidating its mechanisms of action in muscle cells and calcium homeostasis. Recent studies have focused on the characterization of STAC3 through recombinant protein expression and functional assays, providing insights into its interaction with CaV1.1 and downstream signaling pathways. This research not only enhances our understanding of STAC3-related pathologies but also lays the groundwork for potential therapeutic interventions aimed at mitigating the effects of STAC3 mutations in affected individuals, highlighting the protein's significance in both basic and applied biomedical research.
