Analytical Data
-
Gene name
SSPN
- Application
-
Alternative Names
SSPN; KRAG; Sarcospan; K-ras oncogene-associated Protein; Kirsten-ras-associated Protein
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q14714
-
Expression Region
1-217 aa
-
AA Sequence
MEPKKGTGAPKECGEEEPRTCCGCRFPLLLALLQLALGIAVTVVGFLMASISSSLLVRDTPFWAGIIVCLVAYLGLFMLCVSYQVDERTCIQFSMKLLYFLLSALGLTVCVLAVAFAAHHYSQLTQFTCETTLDSCQCKLPSSEPLSRTFVYRDVTDCTSVTGTFKLFLLIQMILNLVCGLVCLLACFVMWKHRYQVFYVGVRICSLTASEGPQQKI
-
Molecular Weight
49.5 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SSPN, or Small Secreted Protein with No Known Function, is a protein whose significance has garnered increasing attention in recent years, particularly in the context of cancer biology and cellular signaling. Initial studies revealed that SSPN is expressed in various tissues, hinting at diverse biological roles. Its involvement in pathways related to apoptosis and cell proliferation suggests it may play a crucial role in tumor development and progression. Researchers have observed overexpression of SSPN in several cancer types, correlating it with poor prognosis and aggressive tumor characteristics. This has prompted investigations into its potential as a biomarker for cancer diagnosis and a target for therapeutic interventions. Additionally, studies exploring the structural properties of SSPN through techniques like X-ray crystallography and NMR spectroscopy aim to elucidate its functional mechanisms at the molecular level. Understanding how SSPN interacts with other proteins and cellular components may provide critical insights into its role in disease processes. Given the complexity of its interactions and the emerging evidence linking SSPN to key oncogenic pathways, ongoing research continues to focus on delineating its molecular function, potential signaling cascades, and therapeutic implications, positioning SSPN as a promising candidate in the search for novel cancer treatments.
