Analytical Data
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基因名
Smad9
- Application
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别名
Smad9；MADH6；MADH9；SMAD8；Mothers against decapentaplegic homolog 9
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15198
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表达区间
1-467aa
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氨基酸序列
MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKG AMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPD LQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEY NPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQS PCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQSGQPVDATAD RHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDG FTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECV SDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHH GFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLD KVLTQMGSPHNPISSVS
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分子量
86 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Smad9 is a member of the Smad protein family, which plays a crucial role in the transforming growth factor-beta (TGF-β) signaling pathway. This pathway is essential for various biological processes, including cell growth, differentiation, and apoptosis. Smad9, in particular, is involved in mediating the effects of certain TGF-β superfamily members, such as inhibin, which are important in reproductive biology and organ development. The dysregulation of Smad9 expression or function has been implicated in various diseases, including fibrosis, cancer, and developmental disorders. Recent studies have focused on the characterization of recombinant Smad9 proteins to better understand its structural and functional properties. The production of these recombinant proteins allows researchers to investigate the molecular mechanisms through which Smad9 interacts with other signaling molecules, as well as its role in cellular responses to extracellular signals. By analyzing the activity of recombinant Smad9, scientists aim to elucidate its contributions to the TGF-β signaling pathway and identify potential therapeutic targets for diseases associated with its dysfunction. This research is vital not only for understanding fundamental cellular processes but also for developing strategies to manipulate this pathway for therapeutic benefit in various pathological conditions.
