Analytical Data
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Gene name
SPIC
- Application
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Alternative Names
AU019198; C76795; MGC40611; MGC80555; Prf; Pu.1 related factor; Spi C; Spi C transcription factor; Spi-C transcription factor (Spi-1/PU.1 related); spiC; SPIC_HUMAN; Transcription factor Spi-C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N5J4
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Expression Region
1-248aa
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AA Sequence
MTCVEQDKLG QAFEDAFEVL RQHSTGDLQY SPDYRNYLAL INHRPHVKGN SSCYGVLPTE EPVYNWRTVI NSAADFYFEG NIHQSLQNIT ENQLVQPTLL QQKGGKGRKK LRLFEYLHES LYNPEMASCI QWVDKTKGIF QFVSKNKEKL AELWGKRKGN RKTMTYQKMA RALRNYGRSG EITKIRRKLT YQFSEAILQR LSPSYFLGKE IFYSQCVQPD QEYLSLNNWN ANYNYTYANY HELNHHDC
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Molecular Weight
29.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SPIC (Spleen Pri Splicing Factor and Interferon-inducible Protein) is a member of the SPF/SRF family of proteins, primarily recognized for its role in regulating gene expression during immune responses. Recent research highlights its significance in various biological processes, including hematopoiesis, cell differentiation, and response to stress signals. SPIC's ability to modulate gene transcription has made it a focal point of studies in the context of autoimmune diseases, infections, and cancer. The restructured form of SPIC, often engineered to enhance its specificity and functionality, is being explored for its therapeutic potential. By understanding the structural and functional dynamics of SPIC, scientists aim to develop targeted interventions that could manipulate immune responses for better disease management. This research not only sheds light on the intricacies of immune regulation but also opens avenues for novel therapeutic strategies, particularly in conditions where the immune system plays a pivotal role in pathogenesis.
