Analytical Data
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Gene name
SPANXN4
- Application
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Alternative Names
SPANXN4; Sperm protein associated with the nucleus on the X chromosome N4; Nuclear-associated protein SPAN-Xn4; SPANX-N4; SPANX family member N4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5MJ08
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Expression Region
1-99 aa
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AA Sequence
MEEPTSSTNE NKMKSPCESN KRKVDKKKKN LHRASAPEQS LKETEKAKYP TLVFYCRKNK KRNSNQLENN QPTESSTDPI KEKGDLDISA GSPQDGGQN
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Molecular Weight
11.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SPANXN4 is a member of the SPANX gene family, which is known for its roles in spermatogenesis and expression in germ cell tumors. Research into SPANXN4, specifically its recombinant protein, has gained attention due to its potential implications in cancer biology and reproductive health. Understanding the structure and function of SPANXN4 is crucial, as it may serve as a biomarker or therapeutic target in testicular cancer and other malignancies. Previous studies have indicated that SPANXN proteins exhibit specific expression patterns in cancerous tissues compared to normal tissues, suggesting a role in tumorigenesis and development. The recombinant production of SPANXN4 allows for detailed functional assays, enabling researchers to investigate its interactions with other cellular components and its impact on cell signaling pathways. Moreover, studying SPANXN4 can provide insights into its evolutionary significance and potential utility in cancer immunotherapy, given its restricted expression in normal tissues. Ongoing research aims to elucidate the precise mechanisms by which SPANXN4 contributes to tumor development and to explore its potential as a target for therapeutic intervention. Therefore, the study of SPANXN4 recombinant protein is not only relevant for understanding its biological functions but also for advancing strategies in cancer diagnosis and treatment.
