Analytical Data
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基因名
DEGS2
- Application
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别名
DEGS2; C14orf66; Sphingolipid delta(4-desaturase/C4-monooxygenase DES2; Degenerative spermatocyte homolog 2; Sphingolipid 4-desaturase
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6QHC5
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表达区间
1-323aa
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氨基酸序列
MGNSASRSDFEWVYTDQPHTQRRKEILAKYPAIKALMRPDPRLKWAVLVLVLVQMLTCWLVRGLAWRWLLFWAYAFGGCVNHSLTLAIHDISHNAAFGTGRAARNRWLAVFANLPVGVPYAASFKKYHVDHHRYLGGDGLDVDVPTRLEGWFFCTPARKLLWLVLQPFFYSLRPLCVHPKAVTRMEVLNTLVQLAADLAIFALWGLKPVVYLLASSFLGLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNVGYHVEHHDFPSIPGYNLPLVRKIAPEYYDHLPQHHSWVKVLWDFVFEDSLGPYARVKRVYRLAKDGL
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分子量
63.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DEGS2 (delta(3),delta(2)-enoyl-CoA isomerase 2) is a vital enzyme involved in lipid metabolism, particularly in the biosynthesis of sphingolipids. Research into DEGS2 has gained importance due to its potential implications in various physiological and pathological processes, including cellular signaling, development, and the progression of diseases such as cancer and neurodegenerative disorders. DEGS2 catalyzes the isomerization of delta(2)-enoyl-CoA intermediates, playing a crucial role in the remodeling of fatty acids and the synthesis of complex lipids that are essential for cell membrane integrity and function. Studies have revealed its significance in maintaining lipid homeostasis and its potential role in metabolic disorders. Moreover, DEGS2 has emerged as a target for therapeutic interventions, as modulating its activity could influence lipid profiles and cellular signaling pathways. Given the complexities of lipid metabolism and its link to various diseases, investigating the structure, function, and regulation of DEGS2 at a molecular level is critical for understanding its role in health and disease. Recent advances in biochemistry and molecular biology have provided tools to explore DEGS2's properties further, enhancing our comprehension of its functionality and paving the way for potential clinical applications. As the research progresses, it is becoming increasingly clear that DEGS2 is not only integral to lipid metabolism but also holds promise for novel therapeutic strategies aimed at metabolic and inflammatory diseases.
