Analytical Data
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Gene name
SPAG4L
- Application
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Alternative Names
SUN5; SPAG4L; TSARG4; SUN domain-containing protein 5; Sad1 and UNC84 domain-containing protein 5; Sperm-associated antigen 4-like protein; Testis and spermatogenesis-related gene 4 protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TC36
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Expression Region
1-379 aa
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AA Sequence
MPRSSRSPGDPGALLEDVAHNPRPRRIAQRGRNTSRMAEDTSPNMNDNILLPVRNNDQALGLTQCMLGCVSWFTCFACSLRTQAQQVLFNTCRCKLLCQKLMEKTGILLLCAFGFWMFSIHLPSKMKVWQDDSINGPLQSLRLYQEKVRHHSGEIQDLRGSMNQLIAKLQEMEAMSDEQKMAQKIMKMIHGDYIEKPDFALKSIGASIDFEHTSVTYNHEKAHPYWNWIQLWNYAQPPDVILEPNVTPGNCWAFEGDRGQVTIQLAQKVYLSNLTLQHIPKTISLSGSLDTAPKDFVIYGMEGSPKEEVFLGAFQFQPENIIQMFPLQNQPARAFSAVKVKISSNWGNPGFTCLYRVRVHGSVAPPREQPHQNPYPKRD
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Molecular Weight
67.21 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SPAG4L, or Sperm Associated Antigen 4-Like protein, is a member of the sperm-associated antigen family, which has garnered interest due to its role in male fertility and reproductive health. This protein is primarily expressed in the testis and is believed to have critical functions related to sperm motility and fertility. Research has shown that SPAG4L is involved in the assembly and stabilization of the sperm axoneme, a structure essential for flagellar motility. Mutations or dysregulation of SPAG4L expression may lead to infertility in males, making it an important target for studies related to reproductive biology. Additionally, SPAG4L has been linked to various cellular processes, including mitosis and cellular signaling pathways, suggesting that it might also play roles beyond reproduction. The investigation of SPAG4L and its mechanisms is crucial not only for understanding the biological basis of male fertility but also for developing potential therapeutic strategies for treating infertility and related disorders. The ongoing characterization of SPAG4L at molecular and biochemical levels is expected to reveal its interactions with other proteins and its contribution to cellular functions, thereby enhancing our understanding of reproductive health and shedding light on possible implications for infertility treatments in the future.
