Analytical Data
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基因名
SOX8
- Application
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别名
MGC24837; SOX 8; Sox8; SOX8_HUMAN; SRY (sex determining region Y) box 8; SRY box 8; SRY box containing gene 8; Transcription factor SOX 8; Transcription factor SOX-8; Transcription factor SOX8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P57073
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表达区间
1-446 aa
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氨基酸序列
MLDMSEARSQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGVAVGGARGDPAEAA DERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGALKAKPHVKRPMNAFMVWAQAARRKL ADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSAK AGHSDSDSGAELGPHPGGGAVYKAEAGLGDGHHHGDHTGQTHGPPTPPTTPKTELQQAGA KPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDAFDVHEFDQYLPLGGPAPPEPG QAYGGAYFHAGASPVWAHKSAPSASASPTETGPPRPHIKTEQPSPGHYGDQPRGSPDYGS CSGQSSATPAAPAGPFAGSQGDYGDLQASSYYGAYPGYAPGLYQYPCFHSPRRPYASPLL NGLALPPAHSPTSHWDQPVYTTLTRP
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分子量
47.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SOX8 is a member of the SRY (Sex-determining Region Y)-related HMG-box (SOX) family of transcription factors, which play crucial roles in embryonic development, cell differentiation, and organogenesis. It is particularly implicated in the development of the central nervous system, as well as in male germ cell development and other tissue-specific functions. Recent studies have highlighted its importance in various diseases, including cancer, where altered expression of SOX8 may contribute to tumor progression and metastasis. Given its pivotal role in both normal physiological processes and pathological conditions, the generation of recombinant SOX8 protein has gained attention for providing insights into its functional mechanisms, interactions with other proteins, and regulatory pathways. Recombinant SOX8 can be utilized in various biochemical assays and structural studies, helping to elucidate its role in gene regulation and signaling pathways. Additionally, understanding the molecular characteristics of SOX8 may pave the way for potential therapeutic applications, offering a means to manipulate its expression or function in disease contexts. Overall, the study of recombinant SOX8 protein serves as a vital tool in advancing our understanding of its biological significance and developing novel strategies for therapeutic interventions.
