Recombinant Human H2AFX Protein，His

H2AFX, a variant of histone H2A, plays a critical role in the cellular response to DNA damage and chromatin remodeling. Its phosphorylation at serine 139 is a key event in the formation of gamma-H2AX, which serves as a marker for double-strand breaks in DNA. This modification facilitates the recruitment of DNA repair proteins to the sites of damage, thereby playing a vital role in maintaining genomic stability. Research on H2AFX recombination proteins has gained momentum due to their implications in various fields, including cancer biology, aging, and neurodegenerative disorders. Understanding the mechanisms by which H2AFX and its phosphorylated forms coordinate DNA repair processes could yield insights into tumorigenesis and treatment resistance in cancers. Moreover, the utilization of recombinant H2AFX proteins in in vitro assays provides a valuable tool for dissecting the complex interactions involved in DNA damage response pathways. Consequently, studies focusing on the structure, regulation, and functional characterization of H2AFX recombinant proteins are essential for advancing our knowledge of chromatin biology and its impact on cellular physiology. This research not only contributes to basic science but also has potential therapeutic implications, as targeting the pathways involving H2AFX may enhance the efficacy of cancer treatment strategies that exploit DNA damage.