Analytical Data
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Gene name
SOX21
- Application
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Alternative Names
SOX A; SOX-A; sox21; SOX21_HUMAN; SOX25; SRY (sex determining region Y) box 21; SRY; SRY box 21; Transcription factor SOX 21; Transcription factor Sox-21
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y651
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Expression Region
1-276 aa
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AA Sequence
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GGVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP PLAYILLPGM GKPQLDPYPA AYAAAL
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Molecular Weight
28.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SOX21 is a member of the SRY-related high mobility group (HMG) box transcription factor family, which plays crucial roles in various biological processes, including embryonic development, cell differentiation, and pluripotency regulation. Recent studies have highlighted SOX21's involvement in neural development and its potential link to various neurodevelopmental disorders. The protein's ability to regulate gene expression makes it a key player in specifying cell fate and influencing developmental pathways. As an essential factor in maintaining the balance between neurogenesis and gliogenesis, SOX21 has garnered attention for its possible implications in regenerative medicine and targeted therapies for neurological conditions. Furthermore, the understanding of its structural and functional properties is critical for elucidating its mechanisms of action within the cell. Therefore, research on the recombinant SOX21 protein aims to provide insights into its biochemical properties, functional interactions, and regulatory networks. This knowledge can pave the way for potential therapeutic strategies by manipulating SOX21 activity to address abnormalities in neural development and associated diseases. The production and characterization of recombinant SOX21 protein are fundamental steps towards achieving these research goals, helping to unravel its role in complex biological systems and its potential as a biomarker or therapeutic target.
