Analytical Data
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Gene name
SEC11C
- Application
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Alternative Names
SEC11C；SEC11L3；SPC21；SPCS4C；Signal peptidase complex catalytic subunit SEC11C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BY50
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Expression Region
49-192aa
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AA Sequence
KGLIVLTGSESPIVVVLSGSMEPAFHRGDLLFLTNFREDPIRAGEIVVFKVEGRDIPIVHRVIKVHEKDNGDIKFLTKGDNNEVDDRGLYKEGQNWLEKKDVVGRARGFLPYVGMVTIIMNDYPKFKYALLAVMGAYVLLKRES
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Molecular Weight
32.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SEC11C is a member of the SEC11 protein family, which plays a crucial role in the secretory pathway of eukaryotic cells. This protein is involved in the processing and trafficking of proteins within the endoplasmic reticulum (ER) and Golgi apparatus. The significance of SEC11C has been underscored by its potential implications in various biological processes, including cell proliferation, differentiation, and apoptosis. Recent studies have suggested that SEC11C may also be linked to certain diseases, such as cancer and neurodegenerative disorders, wherein protein misfolding and trafficking defects contribute to disease pathology. Understanding the structure and function of SEC11C, particularly its interactions with other molecular partners in the secretory pathway, is essential for elucidating its role in cellular health and disease. Researchers have focused on characterizing the recombinant SEC11C protein through various biochemical and biophysical approaches, aiming to uncover its functional mechanisms and potential as a therapeutic target. By employing techniques such as X-ray crystallography, cryo-electron microscopy, and site-directed mutagenesis, scientists are striving to delineate the molecular insights that underpin SEC11C's role in protein secretion and its implications in human health. Ultimately, ongoing investigations into SEC11C could pave the way for novel strategies in treating diseases associated with protein misfolding and trafficking defects.
