Analytical Data
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Gene name
LDB1
- Application
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Alternative Names
LDB1；CLIM2；LIM domain-binding Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86U70
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Expression Region
2-411aa
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AA Sequence
SVGCACPGC SSKSFKLYSP KEPPNGNAFP PFHPGTMLDR DVGPTPMYPP TYLEPGIGRH TPYGNQTDYR IFELNKRLQN WTEECDNLWW DAFTTEFFED DAMLTITFCL EDGPKRYTIG RTLIPRYFRS IFEGGATELY YVLKHPKEAF HSNFVSLDCD QGSMVTQHGK PMFTQVCVEG RLYLEFMFDD MMRIKTWHFS IRQHRELIPR SILAMHAQDP QMLDQLSKNI TRCGLSNSTL NYLRLCVILE PMQELMSRHK TYSLSPRDCL KTCLFQKWQR MVAPPAEPTR QQPSKRRKRK MSGGSTMSSG GGNTNNSNSK KKSPASTFAL SSQVPDVMVV GEPTLMGGEF GDEDERLITR LENTQFDAAN GIDDEDSFNN SPALGANSPW NSKPPSSQES KSENPTSQAS Q
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LDB1 (LIM domain-binding protein 1) is a critical transcriptional co-regulator implicated in various biological processes, including embryonic development, hematopoiesis, and neurogenesis. As a protein that interacts with several transcription factors through its LIM domains, LDB1 has been shown to play a vital role in the formation of protein complexes that drive gene expression. Dysregulation of LDB1 is associated with several diseases, including cancer, making it a potential target for therapeutic interventions. Research into LDB1 recombinant proteins aims to elucidate its functional mechanisms and interactions at the molecular level. By producing LDB1 in a recombinant form, scientists can study its structural properties, binding affinities, and the impact of specific mutations on its activity. This research not only enhances our understanding of LDB1’s physiological roles but also provides insights into how altering its function could contribute to disease pathology. Moreover, recombinant LDB1 can be utilized in drug screening assays to identify small molecules that modulate its activity, further highlighting its therapeutic potential. Overall, LDB1 recombinant protein research serves as a foundational step in deciphering the complex regulatory networks involving this protein and opens avenues for innovative treatments targeting related disorders.
