Analytical Data
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基因名
SNX15
- Application
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别名
Clone iota unknown protein; HSAF001435; SNX 15; SNX15; SNX15_HUMAN; Sorting nexin 15; Sorting nexin-15
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NRS6
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表达区间
1-342 aa
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氨基酸序列
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDVKEVVVWK RYSDFRKLHG DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA EDLLRFTVHI PALNNSPQLK EFFRGGEVTR PLEVSRDLHI LPPPLIPTPP PDDPRLSQLL PAERRGLEEL EVPVDPPPSS PAQEALDLLF NCESTEEASG SPARGPLTEA ELALFDPFSK EEGAAPSPTH VAELATMEVE SARLDQEPWE PGGQEEEEDG EGGPTPAYLS QATELITQAL RDEKAGAYAA ALQGYRDGVH VLLQGVPSDP LPARQEGVKK KAAEYLKRAE EILRLHLSQL PP
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分子量
38.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNX15, a member of the sorting nexin family, has garnered attention in recent years for its potential roles in intracellular trafficking and membrane dynamics. Research indicates that SNX15 participates in the endosomal-lysosomal pathway, where it is involved in the sorting and recycling of membrane proteins. The protein is characterized by the presence of a phosphoinositide-binding PH domain, which suggests its function in recognizing and binding to specific lipid environments within the cell. Understanding the biological functions and mechanisms of SNX15 is crucial, as dysregulation of sorting nexins has been implicated in various diseases, including cancer and neurodegenerative disorders. Recent studies utilizing recombinant SNX15 protein have aimed to elucidate its structure-function relationship and interaction partners, providing insights into its role in membrane trafficking. Moreover, the production of SNX15 as a recombinant protein allows for detailed biochemical and biophysical analyses, such as crystallography or binding assays, to further explore its potential as a therapeutic target. The ongoing research into SNX15 aims to unravel its contributions to cellular homeostasis and its implications in pathophysiological conditions, ultimately seeking to leverage this knowledge for developing novel strategies in disease management.
