Analytical Data
-
Gene name
SNRPN
- Application
-
Alternative Names
HCERN3; PWCR; RSMN_HUMAN; RT LI; RTLI; SM D; Sm N; Sm protein D; Sm protein N; Sm-D; Sm-N; Small nuclear ribonucleoprotein associated protein N; Small nuclear ribonucleoprotein polypeptide N; Small nuclear ribonucleoprotein-associated protein N; SMD; SmN; SNRNP N; snRNP-N; SNRNPN; SNRPN; SNURF SNRPN; Tissue specific splicing protein; Tissue-specific-splicing protein
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P63162
-
Expression Region
1-240 aa
-
AA Sequence
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
-
Molecular Weight
24.6 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N) is a key protein involved in the spliceosomal machinery, particularly in the processing of pre-mRNA into mature mRNA. It plays an essential role in the regulation of gene expression and has been linked to several critical biological processes, including cell differentiation and apoptosis. The SNRPN gene is located in the imprinted Prader-Willi Syndrome (PWS) locus on chromosome 15, and its disruption is associated with various genetic disorders such as PWS and Angelman syndrome. Research on the recombinant SNRPN protein has gained attention due to its potential implications in understanding these syndromes and its functional role in RNA splicing. By producing and characterizing recombinant SNRPN, scientists aim to elucidate its structural properties and functional mechanisms, offering insights that could contribute to the development of therapeutic strategies for genetic disorders. The expressed recombinant protein can be used in biochemical assays to investigate its interactions with other spliceosomal components, providing a clearer understanding of its role in the splicing process and the impact of its dysfunction in disease. Overall, the study of recombinant SNRPN proteins holds promising potential for advancing our knowledge in the fields of molecular biology and genetics, facilitating the search for targeted treatments for syndromes associated with its dysregulation.
