Analytical Data
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基因名
SNRPN
- Application
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别名
HCERN3; PWCR; RSMN_HUMAN; RT LI; RTLI; SM D; Sm N; Sm protein D; Sm protein N; Sm-D; Sm-N; Small nuclear ribonucleoprotein associated protein N; Small nuclear ribonucleoprotein polypeptide N; Small nuclear ribonucleoprotein-associated protein N; SMD; SmN; SNRNP N; snRNP-N; SNRNPN; SNRPN; SNURF SNRPN; Tissue specific splicing protein; Tissue-specific-splicing protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P63162
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表达区间
1-240 aa
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氨基酸序列
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
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分子量
24.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N) is a key protein involved in the spliceosomal machinery, particularly in the processing of pre-mRNA into mature mRNA. It plays an essential role in the regulation of gene expression and has been linked to several critical biological processes, including cell differentiation and apoptosis. The SNRPN gene is located in the imprinted Prader-Willi Syndrome (PWS) locus on chromosome 15, and its disruption is associated with various genetic disorders such as PWS and Angelman syndrome. Research on the recombinant SNRPN protein has gained attention due to its potential implications in understanding these syndromes and its functional role in RNA splicing. By producing and characterizing recombinant SNRPN, scientists aim to elucidate its structural properties and functional mechanisms, offering insights that could contribute to the development of therapeutic strategies for genetic disorders. The expressed recombinant protein can be used in biochemical assays to investigate its interactions with other spliceosomal components, providing a clearer understanding of its role in the splicing process and the impact of its dysfunction in disease. Overall, the study of recombinant SNRPN proteins holds promising potential for advancing our knowledge in the fields of molecular biology and genetics, facilitating the search for targeted treatments for syndromes associated with its dysregulation.
