Analytical Data
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基因名
FBXL3
- Application
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别名
FBXL3；FBL3A；FBXL3A；F-box/LRR-repeat Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKT7
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表达区间
1-428aa
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氨基酸序列
MKRGGRDSDR NSSEEGTAEK SKKLRTTNEH SQTCDWGNLL QDIILQVFKY LPLLDRAHAS QVCRNWNQVF HMPDLWRCFE FELNQPATSY LKATHPELIK QIIKRHSNHL QYVSFKVDSS KESAEAACDI LSQLVNCSLK TLGLISTARP SFMDLPKSHF ISALTVVFVN SKSLSSLKID DTPVDDPSLK VLVANNSDTL KLLKMSSCPH VSPAGILCVA DQCHGLRELA LNYHLLSDEL LLALSSEKHV RLEHLRIDVV SENPGQTHFH TIQKSSWDAF IRHSPKVNLV MYFFLYEEEF DPFFRYEIPA THLYFGRSVS KDVLGRVGMT CPRLVELVVC ANGLRPLDEE LIRIAERCKN LSAIGLGECE VSCSAFVEFV KMCGGRLSQL SIMEEVLIPD QKYSLEQIHW EVSKHLGRVW FPDMMPTW
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXL3 (F-box and leucine-rich repeat protein 3) is a critical component of the ubiquitin-proteasome system, playing a vital role in the regulation of protein degradation and cellular homeostasis. Recent studies have highlighted its involvement in circadian rhythm regulation, whereby FBXL3 acts as a substrate recognition component for the E3 ubiquitin ligase complex, targeting specific proteins for degradation. Aberrations in FBXL3 activity have been linked to various pathologies, including sleep disorders and metabolic syndromes. Additionally, its role in modulating the stability of essential clock proteins like CRY1 and CRY2 underscores its significance in maintaining circadian clock functions. With the growing interest in the circadian biology field, harnessing recombinant FBXL3 proteins has become crucial for elucidating their biochemical pathways, understanding their interactions with other clock proteins, and exploring their therapeutic potential in circadian-related diseases. Thus, research on FBXL3 recombinant proteins offers vital insights into the mechanisms underlying circadian regulation and its broader implications for health and disease.
