Cat: PA2000-3341

Recombinant Human PNMA5 Protein,His

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Analytical Data

  • Gene name

    PNMA5

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    PNMA5;KIAA1934;Paraneoplastic antigen-like Protein 5

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q96PV4

  • Expression Region

    4-442aa

  • AA Sequence

    TLLEDWCKGMDMDPRKALLIVGIPMECSEVEIQDTVKAGLQPLCAYRVLGRMFRREDNAKAVFIELADTVNYTTLPSHIPGKGGSWEVVVKPRNPDDEFLSRLNYFLKDEGRSMTDVARALGCCSLPAESLDAEVMPQVRSPPLEPPKESMWYRKLKVFSGTASPSPGEETFEDWLEQVTEIMPIWQVSEVEKRRRLLESLRGPALSIMRVLQANNDSITVEQCLDALKQIFGDKEDFRASQFRFLQTSPKIGEKVSTFLLRLEPLLQKAVHKSPLSVRSTDMIRLKHLLARVAMTPALRGKLELLDQRGCPPNFLELMKLIRDEEEWENTEAVMKNKEKPSGRGRGASGRQARAEASVSAPQATVQARSFSDSSPQTIQGGLPPLVKRRRLLGSESTRGEDHGQATYPKAENQTPGREGPQAAGEELGNEAGAGAMSH

  • Molecular Weight

    64.9 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

The PNMA5 protein, a member of the paraneoplastic Ma antigens, has garnered significant interest in cancer research due to its potential role as a tumor-associated antigen. Originally identified in patients with paraneoplastic neurological syndromes, PNMA5 is thought to be involved in the immune response against tumors. Its expression is often upregulated in various types of cancer, including small cell lung cancer and other neuroendocrine tumors, making it a promising target for immunotherapy. Studies have suggested that PNMA5 may elicit an immune response, leading to the production of autoantibodies in affected individuals, which could serve as biomarkers for early cancer detection. The recombinant version of PNMA5 is being explored for use in developing diagnostic tests and therapeutic vaccines aimed at enhancing antitumor immunity. Furthermore, understanding its molecular structure and function could provide insights into its role in oncogenesis and the mechanisms by which cancer evades immune surveillance. Ongoing research is focusing on characterizing the immunogenicity of PNMA5 and exploring its potential applications in targeted cancer therapies, highlighting its significance in the evolving landscape of oncology and personalized medicine.

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