Analytical Data
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Gene name
SLC9A3R1
- Application
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Alternative Names
EBP 50; EBP50; Ezrin radixin moesin binding phosphoprotein 50; Ezrin-radixin-moesin-binding phosphoprotein 50; Na(+)/H(+) exchange regulatory cofactor NHE RF; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na+/H+ exchange regulatory co factor; NHERF 1; NHERF; NHERF-1; NHERF1; NHRF1_HUMAN; NPHLOP2; Regulatory cofactor of Na(+)/H(+) exchanger; Slc9a3r1; Sodium hydrogen exchanger regulatory factor 1; Sodium-hydrogen exchanger regulatory factor 1; Sodium/hydrogen exchanger regulatory factor 1; Solute carrier family 9 (sodium/hydrogen exchanger) member 3 regulator 1; Solute carrier family 9 (sodium/hydrogen exchanger); isoform 3 regulatory factor 1; Solute carrier family 9 isoform 3 regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1; Solute carrier family 9 member 3 regulator 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14745
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Expression Region
2-358 aa
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AA Sequence
SADAGAP LPRLCCLEKG PNGYGFHLHG EKGKLGQYIR LVEPGSPAEK AGLLAGDRLV EVNGENVEKE THQQVVSRIR LNAVRLLV VDPETDEQLQ KLGVQVREEL LRAQEAPGQA EPPAEVQG AGNENEPREA DKSHPEQREL RPRLCTMKKG PSGYGFNLHS DKSKPGQFIR SVDPDSPAEA SGLRAQDRIV EVNGVCMEGK QHGDVVSAIR AGGDETKLLV VDRETDEFFK KCRVIPSQEH LNGPLPVPFT NGEIQKENSR EALAELES PRPALVRSAS SDTSEELNSQ DSPPKQDSTA PSSTSSSDPI LDFNISLAMA KERAHQKRSS KRAPQMDWSK KNELFSNL
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Molecular Weight
38.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC9A3R1, also known as Na+/H+ exchanger regulatory factor 1 (NHERF-1), is a pivotal protein involved in the regulation of various sodium/proton exchangers and other integral membrane proteins. Its role in facilitating salt and water transport in epithelial tissues underscores its importance in physiological processes such as renal function and intestinal absorption. Abnormalities in SLC9A3R1 have been linked to several disorders, including cystic fibrosis and renal tubular acidosis, making it a significant target for research. The expression and purification of recombinant SLC9A3R1 enable detailed studies of its structure, function, and interactions with other proteins. Characterizing this protein can provide insights into its mechanism of action and the effects of mutations, potentially leading to novel therapeutic approaches for related diseases. Moreover, understanding the regulatory pathways modulated by SLC9A3R1 can enhance our knowledge of electrolyte balance and fluid homeostasis in the human body, highlighting its relevance in both basic biology and clinical research. Thus, research into the recombinant form of SLC9A3R1 is essential for unraveling its biological significance and therapeutic potential.
