Analytical Data
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Gene name
WDR45
- Application
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Alternative Names
WDR45；WDRX1；WDRXI4；WIPI4；WD repeat domain phosphoinositide-interacting Protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y484
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Expression Region
1-360aa
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AA Sequence
MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF
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Molecular Weight
66.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
WDR45, or WD repeat-containing protein 45, is a gene located on chromosome X that has garnered significant attention due to its association with neurodevelopmental disorders, particularly in females. Mutations in WDR45 are linked to a rare condition known as beta-propeller protein-associated neurodegeneration (BPAN), which manifests in childhood with developmental delays, cognitive impairments, and movement disorders, later progressing to neurological deterioration. Research on WDR45 focuses on its role in cellular processes such as autophagy and neurodevelopment, emphasizing its crucial function in the brain. The protein is characterized by the presence of WD repeats, which are known to facilitate protein-protein interactions, suggesting that WDR45 may play a regulatory role in various cellular pathways. Understanding the biochemical properties and functional mechanisms of WDR45 through studies of its recombinant protein is vital for elucidating the pathophysiology of associated disorders and may pave the way for potential therapeutic interventions. By generating and characterizing WDR45 recombinant protein, researchers aim to explore its structure-function relationships, interactions with other cellular components, and its impact on neurological health, thereby contributing to the broader field of neurobiology and genetic research.
