Analytical Data
-
Gene name
PHLDA1
- Application
-
Alternative Names
PHLDA1；KAP9.2；KRTAP9.2；Keratin-associated Protein 9-2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8WV24
-
Expression Region
1-401aa
-
AA Sequence
MRRAPAAERLLELGFPPRCGRQEPPFPLGVTRGWGRWPIQKRREGARPVPFSERSQEDGRGPAARSSGTLWRIRTRLSLCRDPEPPPPLCLLRVSLLCALRAGGRGSRWGEDGARLLLLPPARAAGNGEAEPSGGPSYAGRMLESSGCKALKEGVLEKRSDGLLQLWKKKCCILTEEGLLLIPPKQLQHQQQQQQQQQQQQQQQPGQGPAEPSQPSGPAVASLEPPVKLKELHFSNMKTVDCVERKGKYMYFTVVMAEGKEIDFRCPQDQGWNAEITLQMVQYKNRQAILAVKSTRQKQQHLVQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPHPHPHPHSHPHSHPHPHPHPHPHQIPHPHPQPHSQPHGHRLLRSTSNSA
-
Molecular Weight
50.5 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PHLDA1 (Pleckstrin Homology-Like Domains A1) is a protein that has gained significant interest in recent years due to its potential roles in various biological processes and its implications in disease. Initially identified as a protein involved in T-cell regulation, PHLDA1 has been linked to apoptosis, cell differentiation, and immune responses. Its role in cancer has become a focal point, as studies demonstrate that PHLDA1 expression is often downregulated in several malignancies, suggesting it may function as a tumor suppressor. Researchers have explored its capacity to inhibit cell growth and induce apoptosis in cancer cells, highlighting its potential as a therapeutic target. Additionally, PHLDA1 has been implicated in metabolic regulation and has shown interactions with several signaling pathways, which further emphasizes its biological significance. The recombination and production of PHLDA1 as a recombinant protein have enabled detailed structural and functional studies, providing insights into its mechanisms of action and interactions at the molecular level. Furthermore, understanding how PHLDA1 operates in both normal and pathological states could contribute to the development of novel diagnostic and therapeutic strategies in oncology and immunology. Therefore, the exploration of PHLDA1 as a recombinant protein not only aids in delineating its biological functions but also helps in assessing its potential utility in clinical applications. Overall, as research advances, the significance of PHLDA1 continues to unfold, revealing its multifaceted roles in health and disease, which warrants further investigation in the context of personalized medicine and targeted therapy.
