Analytical Data
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基因名
ABCC3
- Application
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别名
ABCC3；CMOAT2；MLP2；MRP3；ATP-binding cassette sub-family C member 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15438
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCC3, also known as Multidrug Resistance Protein 3 (MRP3), is a member of the ATP-binding cassette (ABC) transporter family that plays a crucial role in the cellular transport of various substrates, including drugs, conjugated metabolites, and endogenous compounds. Its primary function involves the transport of bile acids and other organic anions, which has significant implications for drug metabolism and detoxification processes in the liver and other tissues. Research into ABCC3 has gained prominence due to its involvement in drug resistance, particularly in cancer therapies where overexpression can lead to reduced efficacy of anticancer drugs. Understanding the structure and function of ABCC3 can provide insights into its mechanisms of action and regulatory pathways. Additionally, mutations or polymorphisms in the ABCC3 gene may influence individual responses to medications and susceptibility to certain diseases. As a result, ABCC3 is a subject of interest in pharmacogenomics, toxicology, and cancer research, with studies focusing on its potential as a therapeutic target or biomarker for optimizing treatment outcomes. Recent advances in recombinant protein technology have enabled the expression and characterization of ABCC3, facilitating deeper investigations into its biochemical properties and interactions with various ligands. This research not only enhances our understanding of transport mechanisms and drug-resistance phenomena but also contributes to the development of new strategies to overcome multidrug resistance in clinical settings.
