Analytical Data
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Gene name
BCOR
- Application
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Alternative Names
BCOR；KIAA1575；BCL-6 corepressor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6W2J9
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Expression Region
全长
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AA Sequence
full
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BCOR (B-Cell Lymphoma Occurrence Region) is a gene that encodes a protein involved in various cellular processes, including transcriptional regulation, development, and differentiation. The study of BCOR recombined proteins has gained significant attention due to their implications in both normal developmental processes and the pathogenesis of various diseases, particularly in hematological malignancies. BCOR has been identified as a critical player in developmental mechanisms, and mutations or dysregulation of this gene can lead to severe congenital disorders and have been associated with cancers such as B-cell lymphomas. Research into BCOR recombination proteins focuses on elucidating their structure, functionality, and the molecular pathways they influence. Through advanced techniques such as CRISPR-Cas9 gene editing, researchers are able to create specific BCOR variants, allowing for detailed studies on the role of BCOR in cell signaling and gene expression. Additionally, the investigation of BCOR's interactions with other proteins and its role in epigenetic regulation has opened new avenues for understanding its contributions to oncogenesis. This research is essential for developing potential therapeutic strategies aimed at targeting BCOR-related pathways to treat malignancies and other disorders where BCOR mutations play a pivotal role. By building a comprehensive understanding of BCOR's role in both healthy and diseased states, scientists aim to pave the way for innovative treatments and improve patient outcomes in BCOR-related diseases.
