Analytical Data
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Gene name
MON1A
- Application
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Alternative Names
MON1A；SAND1；Vacuolar fusion Protein MON1 homolog A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86VX9
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Expression Region
205-555aa
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AA Sequence
DGYKVVFVRRSPLVLVAVARTRQSAQELAQELLYIYYQILSLLTGAQLSHIFQQKQNYDLRRLLSGSERITDNLLQLMARDPSFLMGAARCLPLAAAVRDTVSASLQQARARSLVFSILLARNQLVALVRRKDQFLHPIDLHLLFNLISSSSSFREGEAWTPVCLPKFNAAGFFHAHISYLEPDTDLCLLLVSTDREDFFAVSDCRRRFQERLRKRGAHLALREALRTPYYSVAQVGIPDLRHFLYKSKSSGLFTSPEIEAPYTSEEEQERLLGLYQYLHSRAHNASRPLKTIYYTGPNENLLAWVTGAFELYMCYSPLGTKASAVSAIHKLMRWIRKEEDRLFILTPLTY
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Molecular Weight
56.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MON1A is a crucial protein involved in intracellular transport and membrane trafficking, playing a significant role in the regulation of vesicle dynamics and endosomal function. It is part of the conserved MON1/CzcE protein family, which has garnered attention due to its implications in various cellular processes, including autophagy and lysosomal function. Research into MON1A has expanded significantly in recent years, particularly in the context of its potential links to neurodegenerative diseases and cancer. Studies have indicated that MON1A is essential for the maturation of endosomes and the recycling of receptors, making it a key player in maintaining cellular homeostasis. Its dysfunction can lead to impaired cell signaling and contribute to disease progression. Given its importance, scientists are keenly investigating the biochemical pathways involving MON1A, the protein's interactions with other cellular components, and its potential as a therapeutic target. Furthermore, advances in recombinant protein technology have enabled researchers to produce MON1A in vitro, allowing for detailed structural and functional analyses. This research holds promise for elucidating the molecular mechanisms governing cellular transport processes and could lead to novel strategies for therapeutic intervention in diseases associated with MON1A dysfunction. Understanding the precise role of MON1A in cellular dynamics may ultimately pave the way for the development of targeted therapies that can enhance cell function and combat disease effectively.
